ReviewPhysiology (Bethesda, Md.)2015
Aging and the muscle-bone relationship.
Review in Physiology (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between osteosarcopenia and frailty in older adults: a systematic review and meta-analysis.BMC geriatrics · 2026Pooled it
- Modified step aerobics training and neuromuscular function in osteoporotic patients: a randomized controlled pilot study.Archives of orthopaedic and trauma surgery · 2017Trial
- The relationship between circulating osteocalcin and muscle mass measurements in humans: A systematic review and meta-analysis.Sports medicine and health science · 2026Review
- Using quantitative imaging methods to investigate the association between quadriceps stiffness and knee cartilage volumes.Bone & joint research · 2026Article
- Observational
- Epigenetic transcriptional regulation of skeletal aging: The emerging role of mJournal of orthopaedic translation · 2026Review
- Bariatric Surgery and Metabolic Bone Disease: Crosstalk between Muscle, Adipose Tissue, and Bone.Obesity surgery · 2026Review
- Proteomics of aging: biomarkers for physiological systems and diseases.Frontiers in aging · 2026Review
- Roles of skeletal muscle-derived exosomes in osteoporosis.Journal of translational medicine · 2025Review
- Age- and sex-specific relationships between bone mineral density, abdominal fat, and paravertebral muscle.Scientific reports · 2025Article
- Bone and muscle crosstalk in ageing and disease.Nature reviews. Endocrinology · 2025Review
- Low intensity, high frequency vibration training to improve musculoskeletal function in a mouse model of volumetric muscle loss.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Radiologic anatomic study of the humeral medullary canal.JSES international · 2024Article
- Osteocalcin: Beyond Bones.Endocrinology and metabolism (Seoul, Korea) · 2024Review
- Correlation study between bone metabolic markers, bone mineral density, and sarcopenia.Journal of endocrinological investigation · 2024Article
- Osteosarcopenia: Prevalence and 10-Year Fracture and Mortality Risk - A Longitudinal, Population-Based Study of 75-Year-Old Women.Calcified tissue international · 2024Article
- Health Patterns across Adulthood: An Age-Based Investigation of the Nutritional Status, Homocysteine, and CoQ10 of Bank Staff.Clinics and practice · 2024Article
- Discussion on protein recommendations for supporting muscle and bone health in older adults: a mini review.Frontiers in nutrition · 2024Review
- Tibial bone strength is negatively affected by volumetric muscle loss injury to the adjacent muscle in male mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Research advances in crosstalk between muscle and bone in osteosarcopenia (Review).Experimental and therapeutic medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Aging-induced declines in muscle size and quality are thought to contribute to catabolic alterations in bone, but changes in bone with age also profoundly alter its response to muscle-derived stimuli. This review provides an overview of some of the alterations that occur in muscle and bone with aging, and discusses the cellular and molecular mechanisms that may impact these age-associated changes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.