ArticleCurrent protocols in molecular biology2015
BioTAP-XL: Cross-linking/Tandem Affinity Purification to Study DNA Targets, RNA, and Protein Components of Chromatin-Associated Complexes.
Article in Current protocols in molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
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- Cell state-dependent chromatin targeting in NUT carcinoma.Genetics · 2023Article
- Cell state-dependent chromatin targeting in NUT carcinoma.bioRxiv : the preprint server for biology · 2023Article
- Dissecting Locus-Specific Chromatin Interactions by CRISPR CAPTURE.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Variant Polycomb complexes inScience advances · 2022Article
- ChIP-SICAP: A New Tool to Explore Gene-Regulatory Networks in Candida albicans and Other Yeasts.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Bivalent complexes of PRC1 with orthologs of BRD4 and MOZ/MORF target developmental genes inGenes & development · 2017Article
- Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
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- Proteomics to study DNA-bound and chromatin-associated gene regulatory complexes.Human molecular genetics · 2016Article
- Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila.Genes & development · 2016Article
- Streamlined discovery of cross-linked chromatin complexes and associated histone modifications by mass spectrometry.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains.Genes & development · 2015Article
- Sex comb on midleg (Scm) is a functional link between PcG-repressive complexes in Drosophila.Genes & development · 2015Article
- Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In order to understand how chromatin complexes function in the nucleus, it is important to obtain a comprehensive picture of their protein, DNA, and RNA components, as well as their mutual interactions. This unit presents a chromatin cross-linking approach (BioTAP-XL) that utilizes a special BioTAP-tagged transgenic protein bait along with mass spectrometry to identify protein complex components, and high-throughput sequencing to identify RNA components and DNA binding sites. Full protocols are provided for Drosophila cells and for human cells in culture, along with an additional protocol for Drosophila embryos as the source material. A key element of the approach in all cases is the generation of control data from input chromatin samples.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.