ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2015
Anxiety and depression symptoms in the 2 years following diagnosis of breast or gynaecologic cancer: prevalence, course and determinants of outcome.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02650544 (Efficacy and Safety Analyses of Mirtazapine in the Treatment of Malignant Tumor Related Depression), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety Analyses of Mirtazapine in the Treatment of Malignant Tumor Related Depression: A Phase II, Placebo-controlled, Randomized, Double-blinded Clinical Trial in Advanced Non-small Cell Lung Cancer Patients
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictors of emotional distress a year or more after diagnosis of cancer: A systematic review of the literature.Psycho-oncology · 2018Pooled it
- Moderators of Cognitive Therapy and Bright Light Therapy Effects on Depressive Symptoms in Patients with Breast Cancer.International journal of behavioral medicine · 2019Trial
- Systematic nurse-led consultations based on electronic patient-reported outcomes for women with endometrial or ovarian cancer during chemotherapy-a feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Effect of depression and empowerment on medication adherence in patients with breast cancer: a descriptive survey.BMC nursing · 2025Article
- Recognizing Distress in Cancer Patients in Day Hospital, by Trained Nurses vs. Non-Trained Nurses: A Pilot Study.Healthcare (Basel, Switzerland) · 2024Article
- Prevalence of anxiety and depression and their associated risk factors throughout pregnancy and postpartum: a prospective cross-sectional descriptive multicentred study.BMC pregnancy and childbirth · 2024Article
- Depression and anxiety in cancer patient enrolled in clinical trials with serious adverse events.Cancer medicine · 2023Article
- Depression and anxiety among hemophilia patients enrolled in clinical trials: a multi-center cohort study.Annals of hematology · 2023Article
- Surviving and thriving after breast cancer treatment.The Medical journal of Australia · 2022Article
- Factors associated with and risk factors for depression in cancer patients - A systematic literature review.Translational oncology · 2022Review
- Characterizing Early Changes in Quality of Life in Young Women With Breast Cancer.Frontiers in psychology · 2022Article
- Symptom trajectories in patients with breast cancer: An integrative review.International journal of nursing sciences · 2022Review
- The Significant Role of Depression in Elderly Patients with Bladder Cancer.European urology open science · 2021Article
- Brief Report: Hispanic Patients' Trajectory of Cancer Symptom Burden, Depression, Anxiety, and Quality of Life.Nursing reports (Pavia, Italy) · 2021Article
- The Emotional Status, Attitudes in Decision-Making Process, and Their Impact on Surgical Choices in Korean Breast Cancer Patients.Journal of oncology · 2021Article
- Perceptions of care after end-of-treatment among younger women with different gynecologic cancer diagnoses - a qualitative analysis of written responses submitted via a survey.BMC women's health · 2020Article
- Surgical impact on anxiety of patients with breast cancer: 12-month follow-up prospective longitudinal study.Annals of surgical treatment and research · 2020Article
- Identifying risk factors for depression and anxiety symptoms in patients with chronic lymphocytic leukemia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu.Frontiers in psychiatry · 2020Article
- A New Framework for Narcissism in Health Psychology and Psycho-Oncology.Frontiers in psychology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purposes of this study are to examine the course and prevalence of anxiety and depression over 24 months in women with newly diagnosed breast and gynaecologic cancer and, controlling for demographic and clinical confounders, to test the role of neuroticism and psychiatric history in determining outcome 6, 12, 18 and 24 months post-diagnosis.
methodsParticipants completed the Hospital Anxiety and Depression Scale-anxiety subscale and Centre for Epidemiological Studies Depression Scale on an 8-weekly basis from diagnosis until 96 weeks. Changes over time were analyzed with repeated measures ANOVA. Hierarchical linear regression, adjusted a priori for age, chemotherapy and radiation treatment, living alone, education and tumour stream were used to predict anxiety and depression.
resultsParticipants were 105 women (66 breast, 39 gynaecologic). Rates of anxiety (18.1 %) and depression (33.3 %) were highest at diagnosis. Average rates of anxiety and depression were 5.9 and 22.4 %, respectively. Average scores of anxiety and depression were highest at diagnosis, with improvement at 8 and 40 weeks, respectively, subsequently maintained. Morbidity at diagnosis was particularly acute among women with a treatment history of anxiety/depression or with high neuroticism. These three variables were the best and only predictors over 24 months.
conclusionsWomen are most vulnerable to anxiety and depression at diagnosis, with improvement over time. Morbidity rates are lower than reported elsewhere. Women with high neuroticism and a psychiatric history are at greatest risk for future morbidity after adjusting for confounders. Early identification of these women plus heightened surveillance or early referral to psychosocial services may protect against longer-term morbidity.
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