Evidence map›Paper›PMID 25559009›Full record

Trial reportJournal of the American Heart Association2015

Effects of daily almond consumption on cardiometabolic risk and abdominal adiposity in healthy adults with elevated LDL-cholesterol: a randomized controlled trial.

Claire E Berryman, Sheila G West, Jennifer A Fleming, Peter L Bordi, Penny M Kris-Etherton

2 registry-linked trialsOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 53 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 9 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01101230 nacompletednot on this map

Effects of a Diet Rich in Almonds on LDL Cholesterol, LDL Particle Size, Abdominal Adiposity and Vascular Health

TypeinterventionalSponsorPenn State UniversityRan2009 to 2012Enrolled61ConditionsCardiovascular DiseaseArmsAlmonds
NCT03528031 nacompletednot on this mapstarted 2018, after this paper: background citation

Habitual Diet and Avocado Trial

TypeinterventionalSponsorWake Forest University Health SciencesRan2018 to 2020Enrolled1,008ConditionsIntra-abdominal Fat, Metabolic Syndrome, High Cholesterol, Triglycerides HighArmsIntervention Daily Avocado
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 9 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Claire E BerrymanDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA (C.E.B., S.G.W., J.A.F., P.M.K.E.).
Sheila G WestDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA (C.E.B., S.G.W., J.A.F., P.M.K.E.) Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA (S.G.W.).
Jennifer A FlemingDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA (C.E.B., S.G.W., J.A.F., P.M.K.E.).
Peter L BordiDepartment of Hospitality Management, The Pennsylvania State University, University Park, PA (P.L.B.).
Penny M Kris-EthertonDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA (C.E.B., S.G.W., J.A.F., P.M.K.E.).
Pennsylvania State University · US

Funding

WRITING AND THE DAILY EXPERIENCE OF ILLNESSM01RR010732 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI DONG, CHENG · 1995 to 2009
$29.8M
NCRR NIH HHS M01 RR010732NCRR NIH HHS M01 RR 10732
6 · The paper itself

Abstract

backgroundEvidence consistently shows that almond consumption beneficially affects lipids and lipoproteins. Almonds, however, have not been evaluated in a controlled-feeding setting using a diet design with only a single, calorie-matched food substitution to assess their specific effects on cardiometabolic risk factors. METHODS AND

resultsIn a randomized, 2-period (6 week/period), crossover, controlled-feeding study of 48 individuals with elevated LDL-C (149±3 mg/dL), a cholesterol-lowering diet with almonds (1.5 oz. of almonds/day) was compared to an identical diet with an isocaloric muffin substitution (no almonds/day). Differences in the nutrient profiles of the control (58% CHO, 15% PRO, 26% total fat) and almond (51% CHO, 16% PRO, 32% total fat) diets were due to nutrients inherent to each snack; diets did not differ in saturated fat or cholesterol. The almond diet, compared with the control diet, decreased non-HDL-C (-6.9±2.4 mg/dL; P=0.01) and LDL-C (-5.3±1.9 mg/dL; P=0.01); furthermore, the control diet decreased HDL-C (-1.7±0.6 mg/dL; P<0.01). Almond consumption also reduced abdominal fat (-0.07±0.03 kg; P=0.02) and leg fat (-0.12±0.05 kg; P=0.02), despite no differences in total body weight.

conclusionsAlmonds reduced non-HDL-C, LDL-C, and central adiposity, important risk factors for cardiometabolic dysfunction, while maintaining HDL-C concentrations. Therefore, daily consumption of almonds (1.5 oz.), substituted for a high-carbohydrate snack, may be a simple dietary strategy to prevent the onset of cardiometabolic diseases in healthy individuals. CLINICAL TRIAL REGISTRATION URL: www.clinicaltrials.gov; Unique Identifier: NCT01101230.

Indexed as

Prunus dulcisAbsorptiometry, PhotonAdultAgedApolipoproteinsCardiovascular DiseasesCholesterol, HDLCholesterol, LDLCross-Over StudiesFemaleHealthy VolunteersHumansHypercholesterolemiaMaleMiddle AgedObesity, AbdominalApolipoproteinsCholesterol, HDLCholesterol, LDLabdominal fatcardiometabolic diseasecardiovascular disease risk factorsdietlipids and lipoproteins

Identifiers

PMID25559009
PMCPMC4330049
OpenAlexW2149716174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.