ArticleParasites & vectors2015
Role of the chemokine receptor CCR5-dependent host defense system in Neospora caninum infections.
Article in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Protective efficacy of the NcGRA7-deficient parasite as a live attenuated vaccine against Neospora caninum infection in mice.The Journal of veterinary medical science · 2025Article
- Mitochondrial damage and IL-1β production in monocytes caused byFrontiers in immunology · 2025Article
- Article
- Impact ofPathogens (Basel, Switzerland) · 2020Article
- Neospora caninum infection induces an isolate virulence-dependent pro-inflammatory gene expression profile in bovine monocyte-derived macrophages.Parasites & vectors · 2020Article
- From Signaling Pathways to Distinct Immune Responses: Key Factors for Establishing or CombatingPathogens (Basel, Switzerland) · 2020Review
- Article
- Neospora caninum Dense Granule Protein 7 Regulates the Pathogenesis of Neosporosis by Modulating Host Immune Response.Applied and environmental microbiology · 2018Article
- NLRP3 Inflammasome Participates in Host Response toFrontiers in immunology · 2018Article
- Extracellular Vesicles Secreted byFrontiers in immunology · 2018Article
- Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum.The Journal of veterinary medical science · 2017Review
- NLRP3 inflammasome activation in murine macrophages caused by Neospora caninum infection.Parasites & vectors · 2017Article
- CCR5 knockout suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice.Oncotarget · 2016Article
- Neospora caninum Activates p38 MAPK as an Evasion Mechanism against Innate Immunity.Frontiers in microbiology · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeospora caninum, a Toxoplasma gondii-like obligate intracellular parasite, causes abortion in cattle and neurological signs in canines. To understand neosporosis better, studies on host cell migration and host immune responses during the early phase of infection are important. Although the C-C chemokine receptor 5 (CCR5) plays a crucial role in immune cell migration, the role played by it in protective immunity against N. caninum is poorly understood.
methodsCCR5(-/-) mice were used to investigate their sensitivity levels to N. caninum infection and their ability to activate immune cells against this parasite.
resultsIncreased mortality and neurological impairment were observed in the N. caninum-infected CCR5(-/-) mice. In comparison with wild-type mice, CCR5(-/-) mice experienced poor migration of dendritic cells and natural killer T cells to the site of infection. Dendritic cells in an in vitro culture from CCR5(-/-) mice could not be activated upon infection with N. caninum. Furthermore, higher levels of IFN-γ and CCL5 expression, which are associated with brain tissue damage, were observed in the brain tissue of CCR5(-/-) mice during the acute phase of the infection, while there was no significant difference in the parasite load between the wild-type and CCR5(-/-) animals. Additionally, a primary microglia culture from CCR5(-/-) mice showed lower levels of IL-6 and IL-12 production against N. caninum parasites.
conclusionsOur findings show that migration and activation of immune cells via CCR5 is required for controlling N. caninum parasites during the early phase of the infection.
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