ArticleNature biotechnology2015
Distributing a metabolic pathway among a microbial consortium enhances production of natural products.
Article in Nature biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 277 papers, 1 of them a synthesis that pooled it.
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Who cites it
277 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bioactivity and Biotechnological Overview of Naturally Occurring Compounds from the Dinoflagellate Family Symbiodiniaceae: A Systematic Review.TheScientificWorldJournal · 2021Pooled it
- Engineering an asymmetric cross-feeding consortium inSynthetic and systems biotechnology · 2026Article
- Describing the persistence landscape for introducing microbes into complex communities.Applied and environmental microbiology · 2026Review
- Characterising complex metabolic responses in an engineered, cross-feeding microbial co-culture using quantitative proteomics.New biotechnology · 2026Article
- The impact of evolutionary dynamics and expression plasmid stability on long-term heterologous protein production by yeast.Microbial cell factories · 2026Article
- Quartet: Disentangling positive and negative components of microbial interactions.PLoS computational biology · 2026Article
- Programmable cell-cell adhesion in synthetic yeast communities for improved bioproduction.Nature chemical biology · 2026Article
- Review
- Advances in the heterologous biosynthesis of QS saponins: a review.Microbial cell factories · 2026Review
- Co-cultures of Microalgae and Other Microorganisms: Wastewater Treatment and Production of Value-Added Bioproducts.Applied biochemistry and biotechnology · 2026Review
- Article
- A microbial platform for selective biosynthesis of monoterpene esters.Nature communications · 2026Article
- Advances, opportunities, and challenges in microbial community construction: from environmental remediation to biomanufacturing.Archives of microbiology · 2026Review
- Convergent Evolution and De Novo Reconstitution of Apiin Biosynthesis.Plant biotechnology journal · 2026Article
- Quorum sensing in bacteria: insights into communication and inhibition strategies-a review.Archives of microbiology · 2026Review
- Metabolic blueprints of monocultures enable prediction and design of synthetic microbial consortia.bioRxiv : the preprint server for biology · 2026Article
- Diterpenoids in medicinal plants: structure, distribution, biological activities, biosynthesis, and bioengineering prospects.Frontiers in plant science · 2026Review
- Cooperativity in microbial biotechnology: synthetic consortia as emerging metabolic engineering strategy for sustainable bioproduction.Frontiers in bioengineering and biotechnology · 2026Review
- Constraint-Based Modeling of Microbial Communities for Metabolite Production.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Engineering microbial consortia for mixed plastic upcycling.Nature communications · 2025Article
217 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Metabolic engineering of microorganisms such as Escherichia coli and Saccharomyces cerevisiae to produce high-value natural metabolites is often done through functional reconstitution of long metabolic pathways. Problems arise when parts of pathways require specialized environments or compartments for optimal function. Here we solve this problem through co-culture of engineered organisms, each of which contains the part of the pathway that it is best suited to hosting. In one example, we divided the synthetic pathway for the acetylated diol paclitaxel precursor into two modules, expressed in either S. cerevisiae or E. coli, neither of which can produce the paclitaxel precursor on their own. Stable co-culture in the same bioreactor was achieved by designing a mutualistic relationship between the two species in which a metabolic intermediate produced by E. coli was used and functionalized by yeast. This synthetic consortium produced 33 mg/L oxygenated taxanes, including a monoacetylated dioxygenated taxane. The same method was also used to produce tanshinone precursors and functionalized sesquiterpenes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.