ArticleJournal of clinical imaging science2014
Dedicated Breast CT: Feasibility for Monitoring Neoadjuvant Chemotherapy Treatment.
Article in Journal of clinical imaging science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Development and performance evaluation of an upright dedicated cone-beam breast CT system.Medical physics · 2026Article
- Longitudinal contrast-enhanced cone beam breast computed tomography for monitoring treatment response in breast cancer neoadjuvant therapy: a comprehensive assessment.Breast cancer research : BCR · 2025Article
- Comparative analysis of preoperative contrast-enhanced cone beam breast CT (CE-CBBCT) and MRI for differentiating pathological complete response from minimal residual disease in breast cancer.BMC medical imaging · 2025Article
- Breast cancer assessment under neoadjuvant systemic therapy using thoracic photon-counting detector computed tomography in prone position: a pilot study.European radiology experimental · 2025Article
- Breast dosimetry in alternative X-ray-based imaging modalities used in current clinical practices.European journal of radiology · 2022Review
- Dedicated breast CT: state of the art-Part II. Clinical application and future outlook.European radiology · 2022Review
- Breast Cancer Screening: Opportunities and Challenges with Fully 3D Tomographic X-Ray Imaging.Bridge (Washington, D.C. : 1969) · 2022Article
- Assessment of Cone-Beam Breast Computed Tomography for Predicting Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer: A Prospective Study.Journal of oncology · 2022Article
- Single-pass metal artifact reduction using a dual-layer flat panel detector.Medical physics · 2021Article
- Radiation dosimetry of a clinical prototype dedicated cone-beam breast CT system with offset detector.Medical physics · 2021Article
- Sparse-view, short-scan, dedicated cone-beam breast computed tomography: image quality assessment.Biomedical physics & engineering express · 2020Article
- Cone-beam breast computed tomography using ultra-fast image reconstruction with constrained, total-variation minimization for suppression of artifacts.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2020Article
- Dedicated cone-beam breast CT using laterally-shifted detector geometry: Quantitative analysis of feasibility for clinical translation.Journal of X-ray science and technology · 2020Article
- Emerging Breast Imaging Technologies on the Horizon.Seminars in ultrasound, CT, and MR · 2018Article
- Newer Technologies in Breast Cancer Imaging: Dedicated Cone-Beam Breast Computed Tomography.Seminars in ultrasound, CT, and MR · 2018Review
- X-ray scatter correction for dedicated cone beam breast CT using a forward-projection model.Medical physics · 2017Article
- Digital Breast Tomosynthesis guided Near Infrared Spectroscopy: Volumetric estimates of fibroglandular fraction and breast density from tomosynthesis reconstructions.Biomedical physics & engineering expressArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesIn this prospective pilot study, the feasibility of non-contrast dedicated breast computed tomography (bCT) to determine primary tumor volume and monitor its changes during neoadjuvant chemotherapy (NAC) treatment was investigated. MATERIALS AND
methodsEleven women who underwent NAC were imaged with a clinical prototype dedicated bCT system at three time points - pre-, mid-, and post-treatment. The study radiologist marked the boundary of the primary tumor from which the tumor volume was quantified. An automated algorithm was developed to quantify the primary tumor volume for comparison with radiologist's segmentation. The correlation between pre-treatment tumor volumes from bCT and MRI, and the correlation and concordance in tumor size between post-treatment bCT and pathology were determined.
resultsTumor volumes from automated and radiologist's segmentations were correlated (Pearson's r = 0.935, P < 0.001) and were not different over all time points [P = 0.808, repeated measures analysis of variance (ANOVA)]. Pre-treatment tumor volumes from MRI and bCT were correlated (r = 0.905, P < 0.001). Tumor size from post-treatment bCT was correlated with pathology (r = 0.987, P = 0.002) for invasive ductal carcinoma larger than 5 mm and the maximum difference in tumor size was 0.57 cm. The presence of biopsy clip (3 mm) limited the ability to accurately measure tumors smaller than 5 mm. All study participants were pathologically assessed to be responders, with three subjects experiencing complete pathologic response for invasive cancer and the reminder experiencing partial response. Compared to pre-treatment tumor volume, there was a statistically significant (P = 0.0003, paired t-test) reduction in tumor volume at mid-treatment observed with bCT, with an average tumor volume reduction of 47%.
conclusionsThis pilot study suggests that dedicated non-contrast bCT has the potential to serve as an expedient imaging tool for monitoring tumor volume changes during NAC. Larger studies are needed in future.
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