Evidence map›Paper›PMID 25558270›Full record

ArticleDrug discovery today. Therapeutic strategies2013

From a Cell's Viewpoint: Targeting Mitochondria in Alzheimer's disease.

Emily Ann Carlson, Valasani Koteswara Rao, Shirley ShiDu Yan

Open access · bronzeAbstract read
In one paragraph

Article in Drug discovery today. Therapeutic strategies, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Cells · 2025
    Article
  3. International journal of molecular sciences · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emily Ann CarlsonDepartment of Pharmacology & Toxicology and Higuchi Biosciences Center, School of Pharmacy, University of Kansas, Lawrence, Kansas 66047, USA.
Valasani Koteswara RaoDepartment of Pharmacology & Toxicology and Higuchi Biosciences Center, School of Pharmacy, University of Kansas, Lawrence, Kansas 66047, USA.
Shirley ShiDu YanDepartment of Pharmacology & Toxicology and Higuchi Biosciences Center, School of Pharmacy, University of Kansas, Lawrence, Kansas 66047, USA.
University of Kansas · US

Funding

University of Kansas Alzheimer's Disease Core CentersP30AG035982 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BROOKS, WILLIAM M. · 2011 to 2020
$16.6M
Role of Cyclophilin D in Abeta-induced synaptic injuryR37AG037319 · NIA · UNIVERSITY OF KANSAS LAWRENCE · PI YAN, SHIRLEY SHIDU · 2010 to 2019
$3.1M
Role of LRG-47 (Irgm1) in EAER01NS065482 · NINDS · UNIVERSITY OF KANSAS LAWRENCE · PI YAN, SHIRLEY SHIDU · 2010 to 2014
$1.6M
Structural and Functional Properties of cyclophilin D and Abeta interaction.R01GM095355 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI YAN, SHIRLEY SHIDU · 2010 to 2013
$1.5M
NIA NIH HHS P30 AG035982NIA NIH HHS R37 AG037319NIGMS NIH HHS R01 GM095355NINDS NIH HHS R01 NS065482
6 · The paper itself

Abstract

Mitochondria are well-known cellular organelles widely studied in relation to a variety of disease states, including Alzheimer's disease. With roles in several metabolic processes, numerous signal transduction pathways, and overall cell maintenance and survival, mitochondria are essential to understanding the inner workings of cells. As mitochondria are able to be utilized by diverse illnesses to increase the likelihood of disease progression, targeting specific processes in these organelles could provide beneficial therapeutic options.

Identifiers

PMID25558270
PMCPMC4280837
OpenAlexW1998760319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.