Evidence map›Paper›PMID 25558224›Full record

ArticleNeural regeneration research2012

Effects of Zhichan powder on signal transduction and apoptosis-associated gene expression in the substantia nigra of Parkinson's disease rats.

Jiajun Chen, Jinshu Ma, Yafei Qiu, Shihong Yi, Yongmao Liu, Qingwei Zhou, Pengguo Zhang, Quan Wan, Ye Kuang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jiajun ChenDepartment of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130031, Jilin Province, China.
Jinshu MaDepartment of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China.
Yafei QiuDepartment of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China.
Shihong YiDepartment of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China.
Yongmao LiuDepartment of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China.
Qingwei ZhouDepartment of Biochemistry and Molecular Biology, Institute for Regenerative Medicine, Jilin University, Changchun 130021, Jilin Province, China.
Pengguo ZhangDepartment of Image, Second Clinical Hospital, Jilin University, Changchun 130021, Jilin Province, China.
Quan WanDepartment of Biotechnology, Life Science College, Jilin University, Changchun 130012, Jilin Province, China.
Ye KuangDepartment of Biochemistry and Molecular Biology, Institute for Regenerative Medicine, Jilin University, Changchun 130021, Jilin Province, China.
Jilin University · CNSecond Affiliated Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have shown that Zhichan powder elevated immunity and suppressed oxidation in mice. Rat models of Parkinson's disease were induced by stereotaxically injecting 6-hydroxydopamine into the substantia nigra. The rat models were intragastrically treated with Zhichan powder, which is composed of milkvetch root, ginseng, bunge swallowwort root, himalayan teasel root, Magnolia officinalis, Ligustrum lucidum Ait. and szechwan lovage rhizome. Immunohistochemistry and reverse transcription-PCR results demonstrated that mRNA and protein expression of tumor necrosis factor receptor 1, Fas, caspase-8, cytochrome C, Bax, caspase-3, and p53 significantly increased, but Bcl-2 expression significantly decreased in the substantia nigra of rats with Parkinson's disease. Following Zhichan powder administration, mRNA and protein expression of tumor necrosis factor receptor 1, Fas, caspase-8, cytochrome C, Bax, caspase-3, and p53 diminished, but Bcl-2 expression increased in the rat substantia nigra. These results indicate that Zhichan powder regulates signal transduction protein expression, inhibits apoptosis, and exerts therapeutic effects on Parkinson's disease.

Indexed as

6-hydroxydopamineapoptosisdegenerative diseaseneural regenerationParkinson’s diseasesignal transductionsubstantia nigratraditional Chinese medicineZhichan powder

Identifiers

PMID25558224
PMCPMC4281412
OpenAlexW19399575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.