Evidence map›Paper›PMID 25558221›Full record

ArticleNeural regeneration research2012

Baicalin and deferoxamine alleviate iron accumulation in different brain regions of Parkinson's disease rats.

Pei Xiong, Xin Chen, Chunyan Guo, Nan Zhang, Baocang Ma

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Protective effects of baicalin in aToxicology research · 2021
    Article
  11. Review
  12. Review
  13. Inflaming the Brain with Iron.Antioxidants (Basel, Switzerland) · 2021
    Review
  14. Role of Flavonoids in the Treatment of Iron Overload.Frontiers in cell and developmental biology · 2021
    Review
  15. Baicalin Represses C/EBPOxidative medicine and cellular longevity · 2020
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pei XiongDepartment of Chinese Materia Medica Pharmacology, Traditional Chinese Medicine School, Capital Medical University, Beijing 100069, China.
Xin ChenDepartment of Chinese Materia Medica Pharmacology, Traditional Chinese Medicine School, Capital Medical University, Beijing 100069, China.
Chunyan GuoDepartment of Chinese Materia Medica Pharmacology, Traditional Chinese Medicine School, Capital Medical University, Beijing 100069, China.
Nan ZhangDepartment of Chinese Materia Medica Pharmacology, Traditional Chinese Medicine School, Capital Medical University, Beijing 100069, China.
Baocang MaDepartment of Chinese Materia Medica Pharmacology, Traditional Chinese Medicine School, Capital Medical University, Beijing 100069, China.
Beijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies found that iron accumulates in the substantia nigra of Parkinson's disease patients. However, it is still unclear whether other brain regions have iron accumulation as well. In this experiment, rats with rotenone-induced Parkinson's disease were treated by gastric perfusion of baicalin or intraperitoneal injection of deferoxamine. Immunohistochemical staining demonstrated that iron accumulated not only in the substantia nigra pars compacta, but also significantly in the striatum globus pallidus, the dentate gyrus granular layer of the hippocampus, the dentate-interpositus and the facial nucleus of the cerebellum. Both baicalin and deferoxamine, which are iron chelating agents, significantly inhibited iron deposition in these brain areas, and substantially reduced the loss of tyrosine hydroxylase-positive cells. These chelators also reduced iron content in the substantia nigra. In addition to the substantia nigra, iron deposition was observed in other brain regions as well. Both baicalin and deferoxamine significantly inhibited iron accumulation in different brain regions, and had a protective effect on dopaminergic neurons.

Indexed as

baicalincerebellumdeferoxaminehippocampusironneural regenerationneurodegenerative diseaseParkinson’s diseaseregenerationrotenonestriatumsubstantia nigra

Identifiers

PMID25558221
PMCPMC4281409
OpenAlexW142309841

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.