Evidence map›Paper›PMID 25557944›Full record

ArticleWorld journal of urology2015

Is in vivo analysis of urinary stone composition feasible? Evaluation of an experimental setup of a Raman system coupled to commercial lithotripsy laser fibers.

Arkadiusz Miernik, Yvan Eilers, Christoph Nuese, Carsten Bolwien, Armin Lambrecht, Albrecht Hesse, Jens J Rassweiler, Daniel Schlager, Konrad Wilhelm, Ulrich Wetterauer and 1 more

Abstract read
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In one paragraph

Article in World journal of urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Intracorporeal lithotripsy.Urolithiasis · 2018
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Arkadiusz MiernikDepartment of Urology, University Medical Centre Freiburg, Hugstetterstr. 55, 79106, Freiburg, Germany. arkadiusz.miernik@uniklinik-freiburg.de.
Yvan EilersFraunhofer Institute for Physical Measurement Techniques, Heidenhofstraße 8, 79110, Freiburg, Germany.
Christoph NueseFraunhofer Institute for Physical Measurement Techniques, Heidenhofstraße 8, 79110, Freiburg, Germany.
Carsten BolwienFraunhofer Institute for Physical Measurement Techniques, Heidenhofstraße 8, 79110, Freiburg, Germany.
Armin LambrechtFraunhofer Institute for Physical Measurement Techniques, Heidenhofstraße 8, 79110, Freiburg, Germany.
Albrecht HesseGerman Urinary Stone Analysis Centre Bonn, Friedensplatz 16, 53111, Bonn, Germany.
Jens J RassweilerSLK Kliniken Heilbronn, Department of Urology and Pediatric Urology, University of Heidelberg, Am Gesundbrunnen 20-26, 74078, Heilbronn, Germany.
Daniel SchlagerDepartment of Urology, University Medical Centre Freiburg, Hugstetterstr. 55, 79106, Freiburg, Germany.
Konrad WilhelmDepartment of Urology, University Medical Centre Freiburg, Hugstetterstr. 55, 79106, Freiburg, Germany.
Ulrich WetterauerDepartment of Urology, University Medical Centre Freiburg, Hugstetterstr. 55, 79106, Freiburg, Germany.
Martin SchoenthalerDepartment of Urology, University Medical Centre Freiburg, Hugstetterstr. 55, 79106, Freiburg, Germany.
University Medical Center Freiburg · DEFraunhofer Institute for Physical Measurement Techniques · DESLK-Kliniken Heilbronn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRaman spectroscopy allows immediate analysis of stone composition. In vivo stone analysis during endoscopic treatment may offer advantages concerning surgical strategy and metaphylaxis. Urinary stone components were evaluated utilizing an experimental setup of a Raman system coupled to commercial laser fibers.

methodsSamples of paracetamol (acetaminophen) and human urinary stones with known Raman spectra were analyzed using an experimental Raman system coupled to common commercial lithotripsy laser fibers (200 and 940 µm). Two different excitation lasers were used at wavelengths of 532 and 785 nm. Numerical aperture of the fibers, proportion of reflected light reaching the CCD chip, and integration times were calculated. Mathematical signal correction was performed.

resultsBoth the laser beam profile and the quality of light reflected by the specimens were impaired significantly when used with commercial fibers. Acquired spectra could no longer be assigned to a specific stone composition. Subsequent measurements revealed a strong intrinsic fluorescence of the fibers and poor light acquisition properties leading to a significant decrease in the Raman signal in comparison with a free-beam setup. This was true for both investigated fiber diameters and both wavelengths. Microscopic examination showed highly irregular fiber tip surfaces (both new and used fibers).

conclusionsOur results propose that laser excitation and light acquisition properties of commercial lithotripsy fibers impair detectable Raman signals significantly in a fiber-coupled setting. This study provides essential physical and technological information for the development of an advanced fiber-coupled system able to be used for immediate stone analysis during endoscopic stone therapy.

Indexed as

EndoscopyEquipment DesignFeasibility StudiesHumansLithotripsy, LaserUrinary CalculiCommercial laser fibersLithotripsyRaman spectroscopyUrinary stone analysisUrolithiasis

Identifiers

PMID25557944
OpenAlexW2024190321

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.