Evidence map›Paper›PMID 25557943›Full record

ArticleWorld journal of urology2015

Physical activity and body mass index as predictors of prostate cancer risk.

Alessandra Grotta, Matteo Bottai, Hans-Olov Adami, Swann Arp Adams, Olof Akre, Steven Noel Blair, Daniela Mariosa, Olof Nyrén, Weimin Ye, Pär Stattin and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in World journal of urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Physical Activity in Cancer Prevention and Survival: A Systematic Review.Medicine and science in sports and exercise · 2019
    Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. Physical Activity and Prostate Cancer: An Updated Review.Sports medicine (Auckland, N.Z.) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Alessandra GrottaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden. alessandra.grotta@ki.se.
Matteo BottaiInstitute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden. matteo.bottai@ki.se.
Hans-Olov AdamiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden. hadami@hsph.harvard.edu.
Swann Arp AdamsDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. swann.adams@sc.edu.
Olof AkreDepartment of Medicine, Karolinska Institutet, Solna, Sweden. olof.akre@ki.se.
Steven Noel BlairDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. sblair@mailbox.sc.edu.
Daniela MariosaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden. daniela.mariosa@ki.se.
Olof NyrénDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden. olof.nyren@ki.se.
Weimin YeDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden. weimin.ye@ki.se.
Pär StattinSurgery and Perioperative Sciences, Urology and Andrology, Umeå University Hospital, Umeå, Sweden. par.stattin@umu.se.
Rino BelloccoDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden. rino.bellocco@ki.se.
Ylva Trolle LagerrosUnit of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Solna, Sweden. ylva.trolle@ki.se.
Karolinska Institutet · SEUniversity of South Carolina · USUmeå University · SEUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePhysical activity and body mass index (BMI) are involved in prostate cancer etiology; possible biologic mechanisms include their effects on hormonal levels. Our aim was to investigate the relationship between physical activity, obesity, and prostate cancer.

methodsWe followed a cohort of 13,109 Swedish men for 13 years and investigated the association of self-reported physical activity and BMI at baseline with prostate cancer incidence. We further analyzed whether BMI could modulate effects of physical activity. Occupational, recreational, and total physical activity were analyzed in relation to overall, localized, and advanced prostate cancer.

resultsDuring the study follow-up, we observed a total of 904 cases of prostate cancer (429 localized, 407 advanced, and 68 unclassified). High levels of occupational physical activity were associated with a nonsignificantly decreased risk of overall (HR 0.81, 95 % CI 0.61-1.07), localized (HR 0.75, 95 % CI 0.51-1.12), and advanced (HR 0.85, 95 % CI 0.55-1.31) prostate cancer. We found no association between high BMI and risk of prostate cancer incidence: We observed, however, a significant interaction between BMI and leisure physical activity.

conclusionNo association was confirmed between total physical activity and localized or advanced prostate cancer. The highest, relative to the lowest, level of occupational physical activity tended to be linked to a lower risk of prostate cancer, with a suggested dose-response relationship. We found no association between high BMI and risk of prostate cancer incidence; however, our analyses suggested an interaction between BMI and physical activity during recreational time that merits further investigation in future studies.

Indexed as

Body Mass IndexForecastingFollow-Up StudiesHumansIncidenceMaleMiddle AgedMotor ActivityObesityProstatic NeoplasmsRisk AssessmentRisk FactorsSurveys and QuestionnairesSwedenBody mass indexCohort studyEpidemiologyPhysical activityProstate cancer

Identifiers

PMID25557943
OpenAlexW1966537327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.