ArticleBehavioural brain research2015
Sex differences in sensitivity to the social consequences of acute ethanol and social drinking during adolescence.
Article in Behavioural brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry.Frontiers in neuroscience · 2022Pooled it
- Adolescent ethanol sensitivity may predict temporal patterns of anxiety-like behavior following ethanol withdrawal in male rats.The American journal of drug and alcohol abuse · 2026Article
- Women and alcohol: A call to action.Alcohol, clinical & experimental research · 2026Article
- Patterns of neuronal activation following ethanol-induced social facilitation and social inhibition in adolescent cFos-LacZ male and female rats.Behavioural brain research · 2024Article
- Adolescent intermittent ethanol (AIE) produces lasting, sex-specific changes in rat body fat independent of changes in white blood cell composition.Frontiers in physiology · 2024Article
- Social behavior and neuronal activation in adolescent female Fos-LacZ transgenic rats: Impact of acute ethanol challenge and baseline levels of social preference.Alcohol (Fayetteville, N.Y.) · 2023Article
- FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION.Neuroscience and biobehavioral reviews · 2022Review
- Sex differences in behavioral, cognitive and voluntary ethanol-intake effects in Dexamethasone-induced depression-like state in Wistar rat.AIMS neuroscience · 2022Article
- General Anesthetic Exposure During Early Adolescence Persistently Alters Ethanol Responses.Alcoholism, clinical and experimental research · 2020Article
- Effects of dopamine and serotonin synthesis inhibitors on the ketamine-, d-amphetamine-, and cocaine-induced locomotor activity of preweanling and adolescent rats: sex differences.Behavioural brain research · 2020Article
- From adolescence to late aging: A comprehensive review of social behavior, alcohol, and neuroinflammation across the lifespan.International review of neurobiology · 2019Review
- Late aging alters behavioral sensitivity to ethanol in a sex-specific manner in Fischer 344 rats.Pharmacology, biochemistry, and behavior · 2018Article
- Sex Differences in Photic Entrainment and Sensitivity to Ethanol-Induced Chronodisruption in Adult Mice After Adolescent Intermittent Ethanol Exposure.Alcoholism, clinical and experimental research · 2018Article
- Effects of adolescent alcohol consumption on the brain and behaviour.Nature reviews. Neuroscience · 2018Review
- Gender Differences in Risk Factors for Adolescent Binge Drinking and Implications for Intervention and Prevention.Frontiers in psychiatry · 2017Review
- Chronic intermittent ethanol exposure during adolescence: Effects on stress-induced social alterations and social drinking in adulthood.Brain research · 2017Article
- The neurobiology of social play and its rewarding value in rats.Neuroscience and biobehavioral reviews · 2016Review
- Sex differences in behavior and neural development and their role in adolescent vulnerability to substance use.Behavioural brain research · 2016Review
- Moderate prenatal alcohol exposure increases total length of L1-expressing axons in E15.5 mice.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In human adolescents, sociable males frequently drink to enhance positive emotional states, whereas anxious females often drink to avoid negative affective states. This study used a rat model of adolescence to provide information regarding possible sex differences in contributors to social drinking. The effects of ethanol (0, 0.5, and 0.75g/kg) on play fighting and social preference were assessed on P30, P32, and P34 using a within-subject design. Then animals were tested in a social drinking paradigm (P37-P40), with this testing revealing high drinkers and low drinkers. Sex differences in sensitivity to ethanol emerged among high and low drinkers. High socially drinking males, but not females, when tested prior to drinking sessions, showed significant increases in play fighting at both doses. In low drinking males, play fighting was increased by 0.5g/kg ethanol, whereas the higher dose of 0.75g/kg produced significant decreases in play fighting. High drinking females initially showed low levels of social preference than high drinking males and low drinking females and were extremely sensitive to ethanol-induced enhancement of this social measure. Low social drinkers, both males and females, were more sensitive to the suppressing effects of ethanol on social preference following 0.75g/kg ethanol. These findings indicate that during adolescence enhanced sensitivity to the facilitating effects of ethanol on play fighting is associated with heavy drinking among males, whereas low social preference together with high sensitivity to ethanol-induced enhancement of social preference is related to high social drinking in females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.