ArticleAntiviral research2015
Natural compounds isolated from Brazilian plants are potent inhibitors of hepatitis C virus replication in vitro.
Article in Antiviral research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Promising alkaloids and flavonoids compounds as anti-hepatitis c virus agents: a review.Journal of public health in Africa · 2023Article
- Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates.Molecules (Basel, Switzerland) · 2021Review
- An in vitro study of an Artocarpus heterophyllus substance as a hepatitis C antiviral and its combination with current anti-HCV drugs.BMC complementary medicine and therapies · 2021Article
- Alkaloid and benzopyran compounds of Melicope latifolia fruit exhibit anti-hepatitis C virus activities.BMC complementary medicine and therapies · 2021Article
- Review
- A diarylamine derived from anthranilic acid inhibits ZIKV replication.Scientific reports · 2019Article
- Ecological Insights to Track Cytotoxic Compounds amongMolecules (Basel, Switzerland) · 2019Article
- Plant-derived antivirals against hepatitis c virus infection.Virology journal · 2018Review
- Crude leaf extracts of Piperaceae species downmodulate inflammatory responses by human monocytes.PloS one · 2018Article
- Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry.Scientific reports · 2017Article
- Multiple effects of toxins isolated from Crotalus durissus terrificus on the hepatitis C virus life cycle.PloS one · 2017Article
- In Vitro Study on Anti-Hepatitis C Virus Activity of Spatholobus suberectus Dunn.Molecules (Basel, Switzerland) · 2016Article
- Hepatitis C virus: Promising discoveries and new treatments.World journal of gastroenterology · 2016Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Compounds extracted from plants can provide an alternative approach to new therapies. They present characteristics such as high chemical diversity, lower cost of production and milder or inexistent side effects compared with conventional treatment. The Brazilian flora represents a vast, largely untapped, resource of potential antiviral compounds. In this study, we investigate the antiviral effects of a panel of natural compounds isolated from Brazilian plants species on hepatitis C virus (HCV) genome replication. To do this we used firefly luciferase-based HCV sub-genomic replicons of genotypes 2a (JFH-1), 1b and 3a and the compounds were assessed for their effects on both HCV replication and cellular toxicity. Initial screening of compounds was performed using the maximum non-toxic concentration and 4 compounds that exhibited a useful therapeutic index (favourable ratio of cytotoxicity to antiviral potency) were selected for extra analysis. The compounds APS (EC50=2.3μM), a natural alkaloid isolated from Maytrenus ilicifolia, and the lignans 3(∗)43 (EC50=4.0μM), 3(∗)20 (EC50=8.2μM) and 5(∗)362 (EC50=38.9μM) from Peperomia blanda dramatically inhibited HCV replication as judged by reductions in luciferase activity and HCV protein expression in both the subgenomic and infectious systems. We further show that these compounds are active against a daclatasvir resistance mutant subgenomic replicon. Consistent with inhibition of genome replication, production of infectious JFH-1 virus was significantly reduced by all 4 compounds. These data are the first description of Brazilian natural compounds possessing anti-HCV activity and further analyses are being performed in order to investigate the mode of action of those compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.