SynthesisWorld journal of pediatrics : WJP2015
Weaning of nasal CPAP in preterm infants: who, when and how? a systematic review of the literature.
Synthesis in World journal of pediatrics : WJP, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Weaning strategies for the withdrawal of non-invasive respiratory support applying continuous positive airway pressure in preterm infants: a systematic review and meta-analysis.BMJ paediatrics open · 2020Pooled it
- A comparison of methods of discontinuing nasal CPAP in premature infants <30 weeks gestation: a feasibility study.Journal of perinatology : official journal of the California Perinatal Association · 2021Trial
- Sudden vs Pressure Wean From Nasal Continuous Positive Airway Pressure in Infants Born Before 32 Weeks of Gestation: A Randomized Clinical Trial.JAMA pediatrics · 2018Trial
- Comparison of sprinting vs non-sprinting to wean nasal continuous positive airway pressure off in very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2018Trial
- Sudden versus gradual pressure wean from Nasal CPAP in preterm infants: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2017Trial
- Comparison of methods of Weaning from Nasal Continuous Positive Airway Pressure in Preterm Infants: A Randomized Controlled Trial.Pakistan journal of medical sciences · 2026Article
- Lung ultrasound aeration scores and their utility in predicting success of weaning off respiratory support in preterm neonates-A prospective cohort study.European journal of pediatrics · 2025Article
- Duration of continuous positive airway pressure: associations with length of stay and oral feeding patterns in a level IV neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Extending CPAP in stable preterm infants to increase lung growth and development as measured by pulmonary function testing.Seminars in perinatology · 2025Review
- Noninvasive Respiratory Support Weaning in Infants With Severe Bronchiolitis: High Flow Nasal Cannula May Reduce the Length of Stay.Pediatric pulmonology · 2025Observational
- Early successful weaning from continuous positive airway pressure in infants <32 weeks of gestation: predictors of success.Frontiers in pediatrics · 2025Article
- Point-of-care lung ultrasound for continuous positive airway pressure discontinuation in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Management of neonates with respiratory distress syndrome in resource-limited settings.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024Article
- Comparison of Two Methods for Weaning from Nasal Continuous Positive Airway Pressure via the Cyclic Use of High-Flow Nasal Cannula or Room Air in Preterm Infants.Children (Basel, Switzerland) · 2024Article
- Complications associated with incorrect use of nasal CPAP.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Non-invasive ventilation in neonates: a review of current literature.Frontiers in pediatrics · 2023Review
- Use of noninvasive mechanical ventilation weaning protocol in neonatal intensive care units in Brazil: a descriptive study.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2023Article
- Model-Base Estimation of Non-Invasive Ventilation Weaning of Preterm Infants Exposed to Osteopathic Manipulative Treatment: A Propensity-Score-Matched Cohort Study.Healthcare (Basel, Switzerland) · 2022Article
- Noninvasive Ventilation in Preterm Infants: Factors Influencing Weaning Decisions and the Role of the Silverman-Andersen Score.Children (Basel, Switzerland) · 2022Article
- A randomised trial comparing weaning from CPAP alone with weaning using heated humidified high flow nasal cannula in very preterm infants: the CHiPS study.Archives of disease in childhood. Fetal and neonatal edition · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThere is increased use of early nasal continuous positive airway pressure (NCPAP) to manage respiratory distress in preterm infants but optimal methods and factors associated with successful wean are not well defined. A systematic review was performed to define the corrected gestational age (CGA), weight to wean NCPAP and the methods associated with successful weaning of the NCPAP among preterm infants, along with factors affecting it.
methodsSearches were made of PubMed using the keywords-NCPAP, CPAP, weaning, withdrawal, preterm, and infants from its inception to January 1st, 2014, for studies in all languages but limited to humans. Previous reviews (including cross references) were also searched. We included all randomized and quasi-randomized controlled trials where preterm neonates were randomized to different NCPAP weaning strategies. Details of CGA, weight and methods used for weaning NCPAP were extracted along with factors which affect its withdrawal.
resultsSeven studies met the search criteria. The successful wean was at 32 to 33 weeks CGA and at 1600 g. Three different methods were used for weaning were sudden, gradual pressure wean and gradual graded time off wean. Criteria for readiness, success and failure to wean were defined. Factors affecting successful weaning were intubation, anemia, infection and gastro-esophageal reflux.
conclusionsThe successful wean was at 32 to 33 weeks CGA and 1600 g. Criteria for readiness, success and failure to wean are well defined. Sudden weaning may be associated with a shorter weaning time. Future trials are needed comparing weaning methods using defined criteria for readiness and success of NCPAP wean and stratify the results by gestational age and birth weight.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.