ArticleTraffic (Copenhagen, Denmark)2015
Atg27 tyrosine sorting motif is important for its trafficking and Atg9 localization.
Article in Traffic (Copenhagen, Denmark), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Recycling of Vps68 depends on retromer and Mvp1/SNX8.Biology open · 2026Article
- Autophagy-deficient budding yeast cells are sensitive to freeze-thaw stress.microPublication biology · 2025Article
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- Yeast cell death pathway requiring AP-3 vesicle trafficking leads to vacuole/lysosome membrane permeabilization.Cell reports · 2022Article
- A lysosomal biogenesis map reveals the cargo spectrum of yeast vacuolar protein targeting pathways.The Journal of cell biology · 2022Article
- Vps501, a novel vacuolar SNX-BAR protein cooperates with the SEA complex to regulate TORC1 signaling.Traffic (Copenhagen, Denmark) · 2022Article
- YML018C protein localizes to the vacuolar membrane independently of Atg27p.microPublication biology · 2021Article
- Autophagy as an on-ramp to scientific discovery.Autophagy · 2021Article
- Atg27p co-fractionates with clathrin-coated vesicles in budding yeast.microPublication biology · 2021Article
- Atg27p localization is clathrin- and Ent3p/5p-dependent.microPublication biology · 2021Article
- Elevating PI3P drives select downstream membrane trafficking pathways.Molecular biology of the cell · 2021Article
- Article
- Mechanisms governing autophagosome biogenesis.Nature reviews. Molecular cell biology · 2020Review
- Kinetic assay of starvation sensitivity in yeast autophagy mutants allows for the identification of intermediary phenotypes.BMC research notes · 2019Article
- Rsp5 Ubiquitin ligase-mediated quality control system clears membrane proteins mistargeted to the vacuole membrane.The Journal of cell biology · 2019Article
- Membrane protein recycling from the vacuole/lysosome membrane.The Journal of cell biology · 2018Article
- Origin of the Autophagosome Membrane in Mammals.BioMed research international · 2018Review
- Autophagy in the context of the cellular membrane-trafficking system: the enigma of Atg9 vesicles.Biochemical Society transactions · 2017Review
- The Roles of the SNARE Protein Sed5 in Autophagy in Saccharomyces cerevisiae.Molecules and cells · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
During autophagy, the transmembrane protein Atg27 facilitates transport of the major autophagy membrane protein Atg9 to the preautophagosomal structure (PAS). To better understand the function of Atg27 and its relationship with Atg9, Atg27 trafficking and localization were examined. Atg27 localized to endosomes and the vacuolar membrane, in addition to previously described PAS, Golgi and Atg9-positive structures. Atg27 vacuolar membrane localization was dependent on the adaptor AP-3, which mediates direct transport from the trans-Golgi to the vacuole. The four C-terminal amino acids (YSAV) of Atg27 comprise a tyrosine sorting motif. Mutation of the YSAV abrogated Atg27 transport to the vacuolar membrane and affected its distribution in TGN/endosomal compartments, while PAS localization was normal. Also, in atg27(ΔYSAV) or AP-3 mutants, accumulation of Atg9 in the vacuolar lumen was observed upon autophagy induction. Nevertheless, PAS localization of Atg9 was normal in atg27(ΔYSAV) cells. The vacuole lumen localization of Atg9 was dependent on transport through the multivesicular body, as Atg9 accumulated in the class E compartment and vacuole membrane in atg27(ΔYSAV) vps4Δ but not in ATG27 vps4Δ cells. We suggest that Atg27 has an additional role to retain Atg9 in endosomal reservoirs that can be mobilized during autophagy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.