ArticleNature communications2015
AtPHT4;4 is a chloroplast-localized ascorbate transporter in Arabidopsis.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
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Who cites it
74 citing papers in PubMed, 177 citations in OpenAlex.
- Morphophysiological and biochemical leaf responses of Moringa oleifera Lam. to Zn stress during vegetative growth.BMC plant biology · 2026Article
- Electron currents mediated by tonoplast cytochromes b561.European biophysics journal : EBJ · 2026Review
- A node-localized efflux transporter for loading iron to developing tissues in rice.Nature communications · 2025Article
- Mechanisms underpinning natural variation in non-photochemical quenching kinetics.Biochemical Society transactions · 2025Review
- Genome-wide systematic characterization of PHT gene family and its member involved in phosphate uptake in Orychophragmus violaceus.BMC genomics · 2025Article
- Effects of suppression of phosphate transporter 4;4 on COJournal of plant research · 2025Article
- Nucleobase-ascorbate transporter OsNAT9 regulates seed vigor and drought tolerance by modulating ascorbic acid homeostasis in rice.The Plant journal : for cell and molecular biology · 2025Article
- The thylakoid- and pyrenoid-localized phosphate transporter PHT4-9 is essential for photosynthesis in Chlamydomonas.Plant physiology · 2025Article
- Mobilization and recycling of intracellular phosphorus in response to availability.Quantitative plant biology · 2025Review
- Genome-Wide Transcriptional Profiling and Functional Analysis Reveal That OsPHT4;4 Is Critical for the Growth and Development of Rice.International journal of molecular sciences · 2024Article
- The genomics and physiology of abiotic stressors associated with global elevational gradients in Arabidopsis thaliana.The New phytologist · 2024Article
- Horizontal transfer of plasmid-like extrachromosomal circular DNAs across graft junctions in Solanaceae.Molecular horticulture · 2024Article
- Chloroplastic ascorbate modifies plant metabolism and may act as a metabolite signal regardless of oxidative stress.Plant physiology · 2024Article
- Genetically manipulated chloroplast stromal phosphate levels alter photosynthetic efficiency.Plant physiology · 2024Article
- The ascorbate-glutathione cycle coming of age.Journal of experimental botany · 2024Review
- The ascorbate biosynthesis pathway in plants is known, but there is a way to go with understanding control and functions.Journal of experimental botany · 2024Review
- Milestones in understanding transport, sensing, and signaling of the plant nutrient phosphorus.The Plant cell · 2024Review
- Chloroplast phosphate transporter CrPHT4-7 regulates phosphate homeostasis and photosynthesis in Chlamydomonas.Plant physiology · 2024Article
- Article
- The Main Functions of Plastids.Methods in molecular biology (Clifton, N.J.) · 2024Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ascorbate is an antioxidant and coenzyme for various metabolic reactions in vivo. In plant chloroplasts, high ascorbate levels are required to overcome photoinhibition caused by strong light. However, ascorbate is synthesized in the mitochondria and the molecular mechanisms underlying ascorbate transport into chloroplasts are unknown. Here we show that AtPHT4;4, a member of the phosphate transporter 4 family of Arabidopsis thaliana, functions as an ascorbate transporter. In vitro analysis shows that proteoliposomes containing the purified AtPHT4;4 protein exhibit membrane potential- and Cl(-)-dependent ascorbate uptake. The AtPHT4;4 protein is abundantly expressed in the chloroplast envelope membrane. Knockout of AtPHT4;4 results in decreased levels of the reduced form of ascorbate in the leaves and the heat dissipation process of excessive energy during photosynthesis is compromised. Taken together, these observations indicate that the AtPHT4;4 protein is an ascorbate transporter at the chloroplast envelope membrane, which may be required for tolerance to strong light stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.