ArticleAmerican journal of obstetrics and gynecology2015
The preterm placental microbiome varies in association with excess maternal gestational weight gain.
Article in American journal of obstetrics and gynecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.
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Who cites it
111 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Perinatal Bacterial Exposure Contributes to IL-13 Aeroallergen Response.American journal of respiratory cell and molecular biology · 2017Trial
- Longitudinal shifts in oral microbiome composition and metabolic pathways associated with preterm birth.mSystems · 2026Article
- Risk factors for preterm birth in advanced maternal age pregnancies: a retrospective study.BMC pregnancy and childbirth · 2026Review
- Critical assessment of intratumor and low-biomass microbiome using long-read sequencing.bioRxiv : the preprint server for biology · 2026Article
- Crosstalk between the microbiome and the mucosal immunoglobulin A system in the lung, in health and disease.Frontiers in cellular and infection microbiology · 2026Review
- Elevated Micro- and Nanoplastics Detected in Preterm Human Placentae.Research square · 2025Article
- No microorganism was detected in amniotic fluid of healthy pregnancies from the second trimester to the delivery.Microbiome · 2025Article
- Assessment of the placental microbiota of preterm infants with pneumonia: a case control study.Frontiers in cellular and infection microbiology · 2025Article
- Analysis of metagenomic data.Nature reviews. Methods primers · 2025Article
- Gestational Interrelationships among Gut-Metabolism-Transcriptome in Regulating Early Embryo Implantation and Placental Development in Mice.Microorganisms · 2024Article
- Placental TLR recognition of salivary and subgingival microbiota is associated with pregnancy complications.Microbiome · 2024Article
- Maternal microbiota communicates with the fetus through microbiota-derived extracellular vesicles.Microbiome · 2023Article
- Maternal Nutritional Status and the Microbiome across the Pregnancy and the Post-Partum Period.Microorganisms · 2023Review
- Review
- Is there a placental microbiota? A critical review and re-analysis of published placental microbiota datasets.BMC microbiology · 2023Review
- SERUM GLP-2 is Increased in Association with Excess Gestational Weight Gain.American journal of perinatology · 2023Article
- Microbiome-Induced Autoimmunity and Novel Therapeutic Intervention.Advances in experimental medicine and biology · 2023Review
- Complex interplay of gut microbiota between obesity and asthma in children.Frontiers in microbiology · 2023Review
- Amplification of microbial DNA from bacterial extracellular vesicles from human placenta.Frontiers in microbiology · 2023Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveAlthough a higher maternal body mass index is associated with preterm birth, it is unclear whether excess gestational weight gain (GWG) or obesity drives increased risk. We and others have shown that the placenta harbors microbiota, which is significantly different among preterm births. Our aim in this study was to investigate whether the preterm placental microbiome varies by virtue of obesity or alternately by excess GWG. STUDY
designPlacentas (n=320) were collected from term and preterm pregnancies. Genomic DNA was extracted and subjected to metagenomic sequencing. Data were analyzed by clinical covariates that included the 2009 Institute of Medicine's GWG guideline and obesity.
resultsAnalysis of 16S recombinant RNA-based metagenomics revealed no clustering of the microbiome by virtue of obesity (P=.161). Among women who spontaneously delivered preterm, there was again no clustering by obesity (P=.480), but there was significant clustering by excess GWG (P=.022). Moreover, among preterm births, detailed analysis identified microbial genera (family and genus level) and bacterial metabolic gene pathways that varied among pregnancies with excess GWG. Notably, excess GWG was associated with decreased microbial folate biosynthesis pathways and decreased butanoate metabolism (linear discriminate analysis, >3.0-fold).
conclusionAlthough there were no significant alterations in the microbiome by virtue of obesity per se, excess GWG was associated with an altered microbiome and its metabolic profile among those women who experienced a preterm birth.
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