ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2015
Rhinitis in the first 18 months of life: exploring the role of respiratory viruses.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Impact of particulate matter 2.5 exposure on severity of pediatric chronic rhinitis: A prospective cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Blood eosinophil related to maternal allergic rhinitis is associated with the incidence of allergic rhinitis in offspring: COCOA study.BMC pediatrics · 2023Article
- Viruses in chronic rhinosinusitis: a systematic review.Frontiers in allergy · 2023Review
- Role of maternal tryptophan metabolism in allergic diseases in the offspring.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Atopic dermatitis trajectories to age 8 years in the GUSTO cohort.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Prevalence, comorbidities, diagnosis, and treatment of nonallergic rhinitis: real-world comparison with allergic rhinitis.Clinical and experimental pediatrics · 2021Article
- Targeting Antiviral Pathways for Treatment of Allergic Diseases.Journal of the Pediatric Infectious Diseases Society · 2018Article
- Establishment of the nasal microbiota in the first 18 months of life: Correlation with early-onset rhinitis and wheezing.The Journal of allergy and clinical immunology · 2018Article
- Shellfish/crustacean oral allergy syndrome among national service pre-enlistees in Singapore.Asia Pacific allergy · 2018Article
- Effects of Allergic Sensitization on Antiviral Immunity: Allergen, Virus, and Host Cell Mechanisms.Current allergy and asthma reports · 2017Review
- Particularities of allergy in the Tropics.The World Allergy Organization journal · 2016Review
- Rhinitis in the first 18 months of life: exploring the role of respiratory viruses.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2015Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundRhinitis is common in early childhood, but allergic rhinitis is considered a later manifestation of the atopic march. This study aimed to evaluate rhinitis (allergic and non-allergic) in the first 18 months of life, its link with other atopic manifestations and the role of respiratory viruses.
methodsSubjects (n = 1237) of the Singapore GUSTO birth cohort were followed up quarterly until 18 months of age with questionnaires to screen for rhinitis symptoms lasting at least 2 wk and with monthly calls to positive subjects to detect prolonged/recurrent rhinitis symptoms (total duration ≥ 4 wk). Anterior nasal swabbing for molecular-based virus detection was conducted during these visits and near (within a month) rhinitis episodes. Skin prick testing to common environmental and food allergens was conducted at the 18 month visit.
resultsProlonged/recurrent rhinitis was significantly associated with history of parental atopy (mother: aOR = 2.17; father: aOR = 1.82) and atopic comorbidities of eczema (aOR = 2.53) and wheeze (aOR = 4.63) (p < 0.05), though not with allergen sensitization. Although the frequency of nasal respiratory virus detection during scheduled quarterly visits did not differ between prolonged/recurrent rhinitis and matched controls (p > 0.05), virus detection was higher in swabs obtained within a month following rhinitis episodes in prolonged/recurrent rhinitis subjects compared with scheduled visits (adjusted p = 0.04).
conclusionsBased on the duration of rhinitis symptoms, this study defined a subset of early childhood rhinitis which was associated with atopic predisposition and comorbidities. Persistent respiratory viral shedding may contribute to the symptomatology. Whether this entity is a precursor of subsequent childhood allergic rhinitis will require longer follow-up.
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