ArticleCell2015
Subcellular trafficking of FGF controls tracheal invasion of Drosophila flight muscle.
Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- A single-cell atlas of Drosophila trachea reveals glycosylation-mediated Notch signaling in cell fate specification.Nature communications · 2024Article
- A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis in Drosophila secondary cells.PLoS genetics · 2023Article
- REPTOR and CREBRF encode key regulators of muscle energy metabolism.Nature communications · 2023Article
- Adult and Larval Tracheal Systems Exhibit Different Molecular Architectures inInternational journal of molecular sciences · 2023Article
- New developments in the biology of fibroblast growth factors.WIREs mechanisms of disease · 2022Review
- GPI-anchored FGF directs cytoneme-mediated bidirectional contacts to regulate its tissue-specific dispersion.Nature communications · 2022Article
- Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling.Nature communications · 2022Article
- Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms.Nature communications · 2022Article
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- Compartment and cell-type specific hypoxia responses in the developingBiology open · 2020Article
- Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry intoeLife · 2019Article
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- Article
- Development and Function of theGenetics · 2018Review
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- Mechanisms of FGF gradient formation during embryogenesis.Seminars in cell & developmental biology · 2016Review
- New Twists in Drosophila Cell Signaling.The Journal of biological chemistry · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To meet the extreme oxygen demand of insect flight muscle, tracheal (respiratory) tubes ramify not only on its surface, as in other tissues, but also within T-tubules and ultimately surrounding every mitochondrion. Although this remarkable physiological specialization has long been recognized, its cellular and molecular basis is unknown. Here, we show that Drosophila tracheoles invade flight muscle T-tubules through transient surface openings. Like other tracheal branching events, invasion requires the Branchless FGF pathway. However, localization of the FGF chemoattractant changes from all muscle membranes to T-tubules as invasion begins. Core regulators of epithelial basolateral membrane identity localize to T-tubules, and knockdown of AP-1γ, required for basolateral trafficking, redirects FGF from T-tubules to surface, increasing tracheal surface ramification and preventing invasion. We propose that tracheal invasion is controlled by an AP-1-dependent switch in FGF trafficking. Thus, subcellular targeting of a chemoattractant can direct outgrowth to specific domains, including inside the cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.