Evidence map›Paper›PMID 25557063›Full record

ArticlePsychiatry research2015

Clinical high risk and first episode schizophrenia: auditory event-related potentials.

Elisabetta C del Re, Kevin M Spencer, Naoya Oribe, Raquelle I Mesholam-Gately, Jill Goldstein, Martha E Shenton, Tracey Petryshen, Larry J Seidman, Robert W McCarley, Margaret A Niznikiewicz

Abstract read
In one paragraph

Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Auditory event-related potentials and psychosis dimensions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  6. Article
  7. P300 in schizophrenia: Then and now.Biological psychology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elisabetta C del ReVA Boston Healthcare System, Brockton, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Department of Radiology, Brigham and Women׳s Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: elisabetta_delre@hms.harvard.edu.
Kevin M SpencerVA Boston Healthcare System, Brockton, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Naoya OribeVA Boston Healthcare System, Brockton, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Raquelle I Mesholam-GatelyDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Jill GoldsteinHarvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Brigham and Women׳s Hospital, Connors Center for Women׳s Health and Gender Biology, Boston, MA, USA; Departments of Psychiatry and Medicine, Harvard Medical School, Boston, MA, USA.
Martha E ShentonVA Boston Healthcare System, Brockton, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Department of Radiology, Brigham and Women׳s Hospital, Harvard Medical School, Boston, MA, USA.
Tracey PetryshenDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Larry J SeidmanHarvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Robert W McCarleyVA Boston Healthcare System, Brockton, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Margaret A NiznikiewiczVA Boston Healthcare System, Brockton, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Vulnerability to Progression SchizophreniaP50MH080272 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WOO, TSUNGUNG · 2007 to 2011
$9.9M
NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIAR01MH040799 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MCCARLEY, ROBERT W · 1986 to 2011
$6.5M
BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDERR01MH052807 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MCCARLEY, ROBERT W · 1994 to 2009
$3.3M
Electrophysiological Endophenotypes of Schizophrenia in Mouse and ManR01MH093450 · NIMH · GALENEA CORPORATION · PI LEVIN, MARGARET, SPENCER, KEVIN M · 2012 to 2016
$2.9M
Clinical Symptons &Brain Abnormalities in SchizophreniaK05MH070047 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHENTON, MARTHA E. · 2004 to 2008
$581k
Neurophysiological Studies of Visual Perception in SchizophreniaI01CX000154 · VA · VA BOSTON HEALTH CARE SYSTEM · PI SPENCER, KEVIN M · 2009 to 2015
–
CSRD VA I01 CX000154NCRR NIH HHS UL1 RR025758NIMH NIH HHS K05 MH070047NIMH NIH HHS K05MH070047NIMH NIH HHS P50 MH080272NIMH NIH HHS P50MH080272NIMH NIH HHS R01 MH040799NIMH NIH HHS R01 MH052807NIMH NIH HHS R01MH052807NIMH NIH HHS R01MH40799NIMH NIH HHS R01MH50747
6 · The paper itself

Abstract

The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with those during first episode schizophrenia, we cross-sectionally examined sex- and age-matched clinical high risk (CHR, n=21), first episode schizophrenia patients (FESZ, n=20) and matched healthy controls (HC, n=25) on oddball and novelty paradigms and assessed the N100, P200, P3a and P3b as indices of perceptual, attentional and working memory processes. To our knowledge, this is the only such comparison using all of these event-related potentials (ERPs) in two paradigms. We hypothesized that the ERPs would differentiate between the three groups and allow prediction of a diagnostic group. The majority of ERPs were significantly affected in CHR and FESZ compared with controls, with similar effect sizes. Nonetheless, in logistic regression, only the P3a and N100 distinguished CHR and FESZ from healthy controls, suggesting that ERPs not associated with an overt task might be more sensitive to prediction of group membership.

Indexed as

AdultAttentionElectroencephalographyEvent-Related Potentials, P300Evoked Potentials, AuditoryFemaleHumansMalePsychomotor PerformancePsychotic DisordersRiskSchizophreniaYoung AdultN100P200P3aP3b

Identifiers

PMID25557063
PMCPMC4314407

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.