Evidence map›Paper›PMID 25556851›Full record

ArticleChemical communications (Cambridge, England)2015

Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89.

Darpan N Pandya, Sylvie Pailloux, David Tatum, Darren Magda, Thaddeus J Wadas

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. The Evaluation of (1Molecules (Basel, Switzerland) · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Polyazamacrocycle Ligands FacilitateInorganic chemistry · 2020
    Article
  7. Article
  8. Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* forEuropean journal of nuclear medicine and molecular imaging · 2019
    Article
  9. Article
  10. Article
  11. Recent Advances in Zirconium-89 Chelator Development.Molecules (Basel, Switzerland) · 2018
    Review
  12. Bioconjugate chemistry · 2017
    Review
  13. Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89.Chemical communications (Cambridge, England) · 2017
    Article
  14. Investigation of the complexation ofDalton transactions (Cambridge, England : 2003) · 2017
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Darpan N PandyaRadiochemistry Service and Cyclotron Operations, Cancer Biology and Radiology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA. twadas@wakehealth.edu.
Sylvie Pailloux
David Tatum
Darren Magda
Thaddeus J Wadas

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Novel Europium Based Time-Resolve Fluorophore with Exceptional Intensity and StabR43GM090395 · NIGMS · LUMIPHORE, INC. · PI MAGDA, DARREN · 2010 to 2010
$189k
NCATS NIH HHS UL1 TR001420NCI NIH HHS P30 CA012197NIGMS NIH HHS R43 GM090395
6 · The paper itself

Abstract

The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr.

Indexed as

AmidesChelating AgentsCoordination ComplexesHalf-LifeHumansIsotope LabelingPhthalic AcidsPositron-Emission TomographyRadiopharmaceuticalsTissue DistributionZirconiumAmidesChelating AgentsCoordination ComplexesPhthalic AcidsRadiopharmaceuticalsterephthalic acidZirconium

Identifiers

PMID25556851
PMCPMC4507282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.