ArticleThe Journal of physiology2015
Activation of muscarinic receptors by ACh release in hippocampal CA1 depolarizes VIP but has varying effects on parvalbumin-expressing basket cells.
Article in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Molecular and neural circuit mechanisms of parvalbumin (PV) neurons in depression: Insights and advances.iScience · 2026Review
- Voltage imaging of CA1 pyramidal cells and SST+ interneurons reveals stability and plasticity mechanisms of spatial firing.Nature communications · 2026Article
- Learning-dependent feedback by OLM interneurons shapes CA1 representations.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping.Nature communications · 2025Article
- Modulation of speed-dependent acetylcholine release in the hippocampus by spatial task engagement.Cell reports · 2025Article
- Stress-induced changes of the cholinergic circuitry promote retrieval-based generalization of aversive memories.Molecular psychiatry · 2022Article
- Cell-type-specific synaptic modulation of mAChR on SST and PV interneurons.Frontiers in psychiatry · 2022Article
- The Entorhinal Cortical Alvear Pathway Differentially Excites Pyramidal Cells and Interneuron Subtypes in Hippocampal CA1.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Cholinergic Signaling Alters Stress-Induced Sensitization of Hippocampal Contextual Learning.Frontiers in neuroscience · 2019Article
- Acetylcholine Release Inhibits Distinct Excitatory Inputs Onto Hippocampal CA1 Pyramidal Neurons via Different Cellular and Network Mechanisms.Frontiers in cellular neuroscience · 2019Article
- Specific Basal Forebrain-Cortical Cholinergic Circuits Coordinate Cognitive Operations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Neural mechanisms of navigation involving interactions of cortical and subcortical structures.Journal of neurophysiology · 2018Review
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Article
- Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors.Frontiers in neural circuits · 2017Review
- Potential roles of cholinergic modulation in the neural coding of location and movement speed.Journal of physiology, Paris · 2016Review
- Neuromodulation of fast-spiking and non-fast-spiking hippocampal CA1 interneurons by human cerebrospinal fluid.The Journal of physiology · 2016Article
- Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.Frontiers in cellular neuroscience · 2015Article
- Article
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3 authors.
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Abstract
key pointsOptogenetically released acetylcholine (ACh) from medial septal afferents activates muscarinic receptors on both vasoactive intestinal peptide-expressing (VIP) and parvalbumin-expressing (PV) basket cells (BCs) in mouse hippocampal CA1. ACh release depolarized VIP BCs whereas PV BCs depolarized, hyperpolarized or produced biphasic responses. Depolarizing responses in VIP or PV BCs resulted in increased amplitudes and frequencies of spontaneous inhibitory postsynaptic currents (sIPSCs) in CA1 pyramidal neurons. The instantaneous frequency of sIPSCs that result from excitation of VIP or PV BCs primarily occurred within the low gamma frequency band (25-50 Hz). We investigated the effect of acetylcholine release on mouse hippocampal CA1 perisomatically projecting interneurons. Acetylcholine was optogenetically released in hippocampal slices by expressing the excitatory optogenetic protein oChIEF-tdTomato in medial septum/diagonal band of Broca cholinergic neurons using Cre recombinase-dependent adeno-associated virally mediated transfection. The effect of optogenetically released acetylcholine was assessed on interneurons expressing Cre recombinase in vasoactive intestinal peptide (VIP) or parvalbumin (PV) interneurons using whole cell patch clamp methods. Acetylcholine released onto VIP interneurons that innervate pyramidal neuron perisomatic regions (basket cells, BCs) were depolarized by muscarinic receptors. Although PV BCs were also excited by muscarinic receptor activation, they more frequently responded with hyperpolarizing or biphasic responses. Muscarinic receptor activation resulting from ACh release increased the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) in downstream hippocampal CA1 pyramidal neurons with peak instantaneous frequencies occurring in both the gamma and theta bandwidths. Both PV and VIP BCs contributed to the increased sIPSC frequency in pyramidal neurons and optogenetic suppression of PV or VIP BCs inhibited sIPSCs occurring in the gamma range. Therefore, we propose acetylcholine release in CA1 has a complex effect on CA1 pyramidal neuron output through varying effects on perisomatically projecting interneurons.
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