ArticleeLife2015
Interplay between population firing stability and single neuron dynamics in hippocampal networks.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 123 citations in OpenAlex.
- Umbrella-type stretchable electrode arrays for long-term neural recording.Nature communications · 2026Article
- Lateral entorhinal cortex supports behaviorally-induced hippocampal ensemble stability for reliable memory recall.bioRxiv : the preprint server for biology · 2026Article
- β-adrenergic receptors modulate CA1 population coding and synaptic plasticity during cumulative spatial memory formation and updating.Scientific reports · 2026Article
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- Homeostasis of a representational map in the neocortex.Nature neuroscience · 2025Article
- In-vivo properties and functional subtypes of gonadotropin-releasing hormone neurons.iScience · 2025Article
- Rapid prey capture learning drives a slow resetting of network activity in rodent binocular visual cortex.bioRxiv : the preprint server for biology · 2025Article
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- Unsupervised restoration of a complex learned behavior after large-scale neuronal perturbation.Nature neuroscience · 2024Article
- Heterogeneous subpopulations of GABAiScience · 2024Article
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- Large-Area Field Potential Imaging Having Single Neuron Resolution Using 236 880 Electrodes CMOS-MEA Technology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease.Nature neuroscience · 2023Article
- Creation of Neuronal Ensembles and Cell-Specific Homeostatic Plasticity through Chronic Sparse Optogenetic Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Paradoxical self-sustained dynamics emerge from orchestrated excitatory and inhibitory homeostatic plasticity rules.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A feedback control principle common to several biological and engineered systems.Journal of the Royal Society, Interface · 2022Review
- The impact of closed-loop intracortical stimulation on neural activity in brain-injured, anesthetized animals.Bioelectronic medicine · 2022Article
- Self-healing codes: How stable neural populations can track continually reconfiguring neural representations.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models.Cell reports · 2022Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Neuronal circuits' ability to maintain the delicate balance between stability and flexibility in changing environments is critical for normal neuronal functioning. However, to what extent individual neurons and neuronal populations maintain internal firing properties remains largely unknown. In this study, we show that distributions of spontaneous population firing rates and synchrony are subject to accurate homeostatic control following increase of synaptic inhibition in cultured hippocampal networks. Reduction in firing rate triggered synaptic and intrinsic adaptive responses operating as global homeostatic mechanisms to maintain firing macro-stability, without achieving local homeostasis at the single-neuron level. Adaptive mechanisms, while stabilizing population firing properties, reduced short-term facilitation essential for synaptic discrimination of input patterns. Thus, invariant ongoing population dynamics emerge from intrinsically unstable activity patterns of individual neurons and synapses. The observed differences in the precision of homeostatic control at different spatial scales challenge cell-autonomous theory of network homeostasis and suggest the existence of network-wide regulation rules.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.