ArticleThe Journal of biological chemistry2015
Structure-function analysis of CCL28 in the development of post-viral asthma.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Immune regulation of neuronal stem cells in the medaka retina.Development (Cambridge, England) · 2026Article
- Are we there yet? understanding interactions between respiratory viral infections, atopy, and the microbiome.Frontiers in allergy · 2026Review
- Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputum.EBioMedicine · 2024Article
- Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences.International journal of molecular sciences · 2023Review
- Rhinovirus infection of the airway epithelium enhances mast cell immune responses via epithelial-derived interferons.The Journal of allergy and clinical immunology · 2023Article
- Atopic Neutrophils Prevent Postviral Airway Disease.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis.Frontiers in immunology · 2021Article
- Chemokine CCL28 Is a Potent Therapeutic Agent for Oropharyngeal Candidiasis.Antimicrobial agents and chemotherapy · 2020Article
- Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H pylori Infection.Cellular and molecular gastroenterology and hepatology · 2019Article
- Review
- The Solution Structure of CCL28 Reveals Structural Lability that Does Not Constrain Antifungal Activity.Journal of molecular biology · 2018Article
- Chemokines from a Structural Perspective.International journal of molecular sciences · 2017Review
- CCL28 chemokine: An anchoring point bridging innate and adaptive immunity.International immunopharmacology · 2017Review
- POL7085 or anti-CCL28 treatment inhibits development of post-paramyxoviral airway disease.Immunity, inflammation and disease · 2017Article
- Production of Recombinant Chemokines and Validation of Refolding.Methods in enzymology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
CCL28 is a human chemokine constitutively expressed by epithelial cells in diverse mucosal tissues and is known to attract a variety of immune cell types including T-cell subsets and eosinophils. Elevated levels of CCL28 have been found in the airways of individuals with asthma, and previous studies have indicated that CCL28 plays a vital role in the acute development of post-viral asthma. Our study builds on this, demonstrating that CCL28 is also important in the chronic post-viral asthma phenotype. In the absence of a viral infection, we also demonstrate that CCL28 is both necessary and sufficient for induction of asthma pathology. Additionally, we present the first effort aimed at elucidating the structural features of CCL28. Chemokines are defined by a conserved tertiary structure composed of a three-stranded β-sheet and a C-terminal α-helix constrained by two disulfide bonds. In addition to the four disulfide bond-forming cysteine residues that define the traditional chemokine fold, CCL28 possesses two additional cysteine residues that form a third disulfide bond. If all disulfide bonds are disrupted, recombinant human CCL28 is no longer able to drive mouse CD4+ T-cell chemotaxis or in vivo airway hyper-reactivity, indicating that the conserved chemokine fold is necessary for its biologic activity. Due to the intimate relationship between CCL28 and asthma pathology, it is clear that CCL28 presents a novel target for the development of alternative asthma therapeutics.
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Registered trials
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