Evidence map›Paper›PMID 25556317›Full record

ArticleNanotechnology2015

The effects of geometry and stability of solid-state nanopores on detecting single DNA molecules.

Ryan Rollings, Edward Graef, Nathan Walsh, Santoshi Nandivada, Mourad Benamara, Jiali Li

Abstract read
In one paragraph

Article in Nanotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Localized Nanopore Fabrication via Controlled Breakdown.Nanomaterials (Basel, Switzerland) · 2022
    Review
  6. Review
  7. Dynamics of DNA Clogging in Hafnium Oxide Nanopores.The journal of physical chemistry. B · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ryan RollingsPhysics Department, University of Arkansas, USA.
Edward GraefPhysics Department, University of Arkansas, USA.
Nathan WalshPhysics Department, University of Arkansas, USA.
Santoshi NandivadaPhysics Department, University of Arkansas, USA.
Mourad BenamaraNanotechnology Center, University of Arkansas, USA.
Jiali LiPhysics Department, University of Arkansas, USA.
University of Arkansas at Fayetteville · US

Funding

Exploration of Solid-state Nanopore Reading Labeled Linear DNA SequenceR21HG004776 · NHGRI · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI LI, JIALI · 2008 to 2012
$1.0M
NHGRI NIH HHS R21 HG004776NHGRI NIH HHS R21HG004776
6 · The paper itself

Abstract

In this work we use a combination of 3D-TEM tomography, energy filtered TEM, single molecule DNA translocation experiments, and numerical modeling to show a more precise relationship between nanopore shape and ionic conductance and show that changes in geometry while in solution can account for most deviations between predicted and measured conductance. We compare the structural stability of ion beam sculpted (IBS), IBS-annealed, and TEM drilled nanopores. We demonstrate that annealing can significantly improve the stability of IBS made pores. Furthermore, the methods developed in this work can be used to predict pore conductance and current drop amplitudes of DNA translocation events for a wide variety of pore geometries. We discuss that chemical dissolution is one mechanism of the geometry change for SiNx nanopores and show that small modification in fabrication procedure can significantly increase the stability of IBS nanopores.

Indexed as

Biosensing TechniquesDNAHumansMicroscopy, Energy-Filtering Transmission ElectronModels, TheoreticalNanoporesDNA

Identifiers

PMID25556317
PMCPMC4288979
OpenAlexW2118559648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.