ArticleMolecular biology and evolution2015
Intraspecific polymorphism, interspecific divergence, and the origins of function-altering mutations in deer mouse hemoglobin.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 131 citations in OpenAlex.
- Plasticity and evolved changes in mitochondrial physiology across skeletal muscles of high-altitude deer mice (Peromyscus maniculatus).The Journal of experimental biology · 2026Article
- Adaptation across an extreme elevational gradient in Andean leaf-eared mice, the world's highest-dwelling mammal.Science (New York, N.Y.) · 2026Article
- Beyond distance-decay: The Mississippi River shapes gut microbiome communities in thebioRxiv : the preprint server for biology · 2026Article
- Evolved increases in running performance in cold hypoxia in high-altitude deer mice.The Journal of experimental biology · 2026Article
- A holistic survey of small mammal diversity across an iconic Madrean Sky Island (Santa Catalina Mountains, Arizona, USA).bioRxiv : the preprint server for biology · 2026Article
- Hemoglobin-Gene Cluster Deletions in Antarctic White-Blooded Icefishes Facilitated by Transposable Elements.Genome biology and evolution · 2025Article
- High-elevation adaptation and gestational hypoxia jointly shape vascular development in a rodent placenta.The Journal of physiology · 2025Article
- To what extent do physiological tolerances determine elevational range limits of mammals?The Journal of physiology · 2024Article
- Local adaptation, plasticity, and evolved resistance to hypoxic cold stress in high-altitude deer mice.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Local adaptation, plasticity, and evolved resistance to hypoxic cold stress in high-altitude deer mice.bioRxiv : the preprint server for biology · 2024Article
- Evolved changes in phenotype across skeletal muscles in deer mice native to high altitude.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Adaptive structural and functional evolution of the placenta protects fetal growth in high-elevation deer mice.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Multiple solutions at the genomic level in response to selective breeding for high locomotor activity.Genetics · 2023Article
- Evolved reductions in body temperature and the metabolic costs of thermoregulation in deer mice native to high altitude.Proceedings. Biological sciences · 2022Article
- Evidence of multiple genome duplication events in Mytilus evolution.BMC genomics · 2022Article
- Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia.Molecular aspects of medicine · 2022Review
- Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice.The Journal of experimental biology · 2022Article
- Time Domains of Hypoxia Responses and -Omics Insights.Frontiers in physiology · 2022Review
- Adrenergic control of the cardiovascular system in deer mice native to high altitude.Current research in physiology · 2022Article
- Broad Concordance in the Spatial Distribution of Adaptive and Neutral Genetic Variation across an Elevational Gradient in Deer Mice.Molecular biology and evolution · 2021Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Major challenges for illuminating the genetic basis of phenotypic evolution are to identify causative mutations, to quantify their functional effects, to trace their origins as new or preexisting variants, and to assess the manner in which segregating variation is transduced into species differences. Here, we report an experimental analysis of genetic variation in hemoglobin (Hb) function within and among species of Peromyscus mice that are native to different elevations. A multilocus survey of sequence variation in the duplicated HBA and HBB genes in Peromyscus maniculatus revealed that function-altering amino acid variants are widely shared among geographically disparate populations from different elevations, and numerous amino acid polymorphisms are also shared with closely related species. Variation in Hb-O2 affinity within and among populations of P. maniculatus is attributable to numerous amino acid mutations that have individually small effects. One especially surprising feature of the Hb polymorphism in P. maniculatus is that an appreciable fraction of functional standing variation in the two transcriptionally active HBA paralogs is attributable to recurrent gene conversion from a tandemly linked HBA pseudogene. Moreover, transpecific polymorphism in the duplicated HBA genes is not solely attributable to incomplete lineage sorting or introgressive hybridization; instead, it is mainly attributable to recurrent interparalog gene conversion that has occurred independently in different species. Partly as a result of concerted evolution between tandemly duplicated globin genes, the same amino acid changes that contribute to variation in Hb function within P. maniculatus also contribute to divergence in Hb function among different species of Peromyscus. In the case of function-altering Hb mutations in Peromyscus, there is no qualitative or quantitative distinction between segregating variants within species and fixed differences between species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.