ArticleApplied and environmental microbiology2015
Non-O1/non-O139 Vibrio cholerae carrying multiple virulence factors and V. cholerae O1 in the Chesapeake Bay, Maryland.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Antimicrobial Resistance of EnvironmentalInfectious disorders drug targets · 2025Pooled it
- Antimicrobial resistance among clinicalPathogens and global health · 2023Pooled it
- Apparent expansion of virulentVirulence · 2026Article
- Frequency of Antimicrobial Resistance Among Fecal Bacteria Pathogens in an Informal Settlement in Nairobi, Kenya, 2018 to 2020.Microorganisms · 2026Article
- Integrated Phenotypic and Genomic Analysis of Antimicrobial Resistance, Virulence, and Phylogeny inMicroorganisms · 2026Article
- Virulence gene profiles and antimicrobial resistance in clinical and environmental isolates of Non-O1/Non-O139 Vibrio cholerae.BMC microbiology · 2026Article
- Chromosome-borneIranian journal of microbiology · 2026Article
- Population structure and phylogenetic analysis of Vibrio cholerae non-O1/O139 by whole genome sequencing.PloS one · 2026Article
- Genomic characterization of non-O1, non-O139 Vibrio cholerae causing rare clinical manifestation.BMC infectious diseases · 2025Article
- Fatal bacteremia caused by novel sequence type 1665 of non-O1/non-O139 Vibrio cholerae: a case report and literature review.BMC infectious diseases · 2025Review
- Genomic Analysis and Virulence Features of Vibrio cholerae Non-O1/Non-O139 Harbouring CARB-Type β-Lactamases From Freshwater Bodies, Argentina.Environmental microbiology reports · 2025Article
- Climate change andProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genomic insights into clinical non-O1/non-O139Microbiology spectrum · 2025Article
- Article
- Wastewater and environmental surveillance forJournal of water and health · 2025Article
- Non-O1/O139 environmental Vibrio cholerae from Northern Cameroon reveals potential intra-/inter-continental transmissions.PLoS neglected tropical diseases · 2025Article
- Vibrio cholerae: Understanding a persistent pathogen in Sub-Saharan Africa and the East Mediterranean Region.Pathogens and disease · 2025Review
- Genomic Insight intoPathogens (Basel, Switzerland) · 2025Article
- Public health aspects ofEFSA journal. European Food Safety Authority · 2024Article
- Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
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Abstract
Non-O1/non-O139 Vibrio cholerae inhabits estuarine and coastal waters globally, but its clinical significance has not been sufficiently investigated, despite the fact that it has been associated with septicemia and gastroenteritis. The emergence of virulent non-O1/non-O139 V. cholerae is consistent with the recognition of new pathogenic variants worldwide. Oyster, sediment, and water samples were collected during a vibrio surveillance program carried out from 2009 to 2012 in the Chesapeake Bay, Maryland. V. cholerae O1 was detected by a direct fluorescent-antibody (DFA) assay but was not successfully cultured, whereas 395 isolates of non-O1/non-O139 V. cholerae were confirmed by multiplex PCR and serology. Only a few of the non-O1/non-O139 V. cholerae isolates were resistant to ampicillin and/or penicillin. Most of the isolates were sensitive to all antibiotics tested, and 77 to 90% carried the El Tor variant hemolysin gene hlyAET, the actin cross-linking repeats in toxin gene rtxA, the hemagglutinin protease gene hap, and the type 6 secretion system. About 19 to 21% of the isolates carried the neuraminidase-encoding gene nanH and/or the heat-stable toxin (NAG-ST), and only 5% contained a type 3 secretion system. None of the non-O1/non-O139 V. cholerae isolates contained Vibrio pathogenicity island-associated genes. However, ctxA, ace, or zot was present in nine isolates. Fifty-five different genotypes showed up to 12 virulence factors, independent of the source of isolation, and represent the first report of both antibiotic susceptibility and virulence associated with non-O1/non-O139 V. cholerae from the Chesapeake Bay. Since these results confirm the presence of potentially pathogenic non-O1/non-O139 V. cholerae, monitoring for total V. cholerae, regardless of serotype, should be done within the context of public health.
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