ArticleNeurotoxicology2015
The effect of the aquatic contaminants bisphenol-A and PCB-95 on the zebrafish lateral line.
Article in Neurotoxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Multi-scale analysis reveals key targets mediating BPA-induced sensorineural hearing loss.Medicine · 2026Article
- Disruption of estrogen signaling by developmental exposure to BPA and TBT causes long term functional deficits in zebrafish retina.Frontiers in pharmacology · 2026Review
- Bisphenol A induces ototoxic injury by ferroptosis pathway: integrated analysis of network toxicology, RNA-sequencing and experimental validation.Frontiers in molecular neuroscience · 2026Article
- The Impact of Polychlorinated Biphenyls on the Development of Zebrafish (Biomedicines · 2024Article
- The effects of prenatal bisphenol A exposure on brain volume of children and young mice.Environmental research · 2022Article
- Urinary phenols and parabens in relation to hearing loss: The National Health and Nutrition Examination Survey.Journal of environmental health science & engineering · 2022Article
- Assessing the toxic effects of bisphenol A in consumed crayfish Astacus leptodactylus using multi biochemical markers.Environmental science and pollution research international · 2022Article
- Hair cell toxicology: With the help of a little fish.Frontiers in cell and developmental biology · 2022Review
- The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function.Frontiers in pharmacology · 2022Review
- Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains.Communications biology · 2021Article
- Zebrafish Optomotor Response and Morphology Are Altered by Transient, Developmental Exposure to Bisphenol-A.Journal of developmental biology · 2021Article
- Effect of Deepwater Horizon Crude Oil Water Accommodated Fraction on Olfactory Function in the Atlantic Stingray, Hypanus sabinus.Scientific reports · 2018Article
- Urban stormwater runoff negatively impacts lateral line development in larval zebrafish and salmon embryos.Scientific reports · 2018Article
- In search of a comprehensible set of endpoints for the routine monitoring of neurotoxicity in vertebrates: sensory perception and nerve transmission in zebrafish (Danio rerio) embryos.Environmental science and pollution research international · 2018Article
- Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Environmental toxicants such as bisphenol-A (BPA) and polychlorinated biphenyls (PCBs) are prevalent in our water supply, soil, and many food products and can profoundly affect the central nervous system. Both BPA and PCBs can disrupt endocrine signaling, which is important for auditory development and function, but the effect of these toxicants on the auditory periphery is not understood. In this study we investigated the effect of PCB-95 and BPA on lateral line development, function, and regeneration in larval zebrafish. The lateral line is a system of mechanosensory hair cells on the exterior of the fish that are homologous to the hair cells located in the mammalian inner ear. We found that PCB-95 had no effect on lateral line development or hair cell survival. BPA also did not affect lateral line development, but instead had a significant effect on both hair cell survival and regeneration. BPA-induced hair cell loss is both dose- and time-dependent, with concentrations of 1 μM or higher killing lateral line hair cells during a 24h exposure period. Pharmacologic manipulation experiments suggest that BPA kills hair cells via activation of oxidative stress pathways, similar to prior reports of BPA toxicity in other tissues. We also observed that hair cells killed with neomycin, a known ototoxin, failed to regenerate normally when BPA was present, suggesting that BPA in aquatic environments could impede innate regenerative responses in fishes. Collectively, these data demonstrate that BPA can have detrimental effects on sensory systems, both in aquatic life and perhaps in terrestrial organisms, including humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.