Evidence map›Paper›PMID 25555840›Full record

ArticleDevelopmental biology2015

Differential regenerative capacity of neonatal mouse hearts after cryoinjury.

Ali Darehzereshki, Nicole Rubin, Laurent Gamba, Jieun Kim, James Fraser, Ying Huang, Joshua Billings, Robabeh Mohammadzadeh, John Wood, David Warburton and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Guidelines for experimental models of myocardial ischemia and infarction.American journal of physiology. Heart and circulatory physiology · 2018
    Guideline
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Animal models to study cardiac regeneration.Nature reviews. Cardiology · 2024
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Advances in 3D Organoid Models for Stem Cell-Based Cardiac Regeneration.International journal of molecular sciences · 2023
    Review
  13. Review
  14. Article
  15. The regenerative capacity of neonatal tissues.Development (Cambridge, England) · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ali DarehzereshkiHeart Institute, Los Angeles, California; The Saban Research Institute of Children׳s Hospital Los Angeles, Los Angeles, California.
Nicole RubinHeart Institute, Los Angeles, California; The Saban Research Institute of Children׳s Hospital Los Angeles, Los Angeles, California.
Laurent GambaHeart Institute, Los Angeles, California; The Saban Research Institute of Children׳s Hospital Los Angeles, Los Angeles, California.
Jieun KimHeart Institute, Los Angeles, California; The Saban Research Institute of Children׳s Hospital Los Angeles, Los Angeles, California.
James FraserHeart Institute, Los Angeles, California; The Saban Research Institute of Children׳s Hospital Los Angeles, Los Angeles, California.
Ying HuangHeart Institute, Los Angeles, California; The Saban Research Institute of Children׳s Hospital Los Angeles, Los Angeles, California.
Joshua BillingsHeart Institute, Los Angeles, California; The Saban Research Institute of Children׳s Hospital Los Angeles, Los Angeles, California.
Robabeh MohammadzadehBroad Center of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, CA.
John WoodHeart Institute, Los Angeles, California; The Saban Research Institute of Children׳s Hospital Los Angeles, Los Angeles, California; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA.
David WarburtonThe Saban Research Institute of Children׳s Hospital Los Angeles, Los Angeles, California; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Vesa KaartinenDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan.
Ching-Ling LienHeart Institute, Los Angeles, California; The Saban Research Institute of Children׳s Hospital Los Angeles, Los Angeles, California; Department of Surgery, Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA. Electronic address: clien@chla.usc.edu.
Children's Hospital of Los Angeles · USUniversity of Southern California · USUniversity of Michigan · US

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Molecular Mechanisms of Zebrafish Heart RegenerationR01HL096121 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI LIEN, CHING-LING E · 2010 to 2014
$2.0M
NHLBI NIH HHS R01 HL096121NHLBI NIH HHS R01HL096121NIGMS NIH HHS K12 GM068524
6 · The paper itself

Abstract

Neonatal mouse hearts fully regenerate after ventricular resection similar to adult zebrafish. We established cryoinjury models to determine if different types and varying degrees of severity in cardiac injuries trigger different responses in neonatal mouse hearts. In contrast to ventricular resection, neonatal mouse hearts fail to regenerate and show severe impairment of cardiac function post transmural cryoinjury. However, neonatal hearts fully recover after non-transmural cryoinjury. Interestingly, cardiomyocyte proliferation does not significantly increase in neonatal mouse hearts after cryoinjuries. Epicardial activation and new coronary vessel formation occur after cryoinjury. The profibrotic marker PAI-1 is highly expressed after transmural but not non-transmural cryoinjuries, which may contribute to the differential scarring. Our results suggest that regenerative medicine strategies for heart injuries should vary depending on the nature of the injury.

Indexed as

FreezingRegenerationAnimalsAnimals, NewbornApoptosisBlood VesselsCaspase 3Cell ProliferationEchocardiographyHeartHeart InjuriesHeart VentriclesImmunohistochemistryMiceModels, CardiovascularMyocytes, CardiacCaspase 3Cardiomyocyte proliferationCryoinjuryEpicardiumNeonatal mouse heart regenerationNeovascularization

Identifiers

PMID25555840
PMCPMC4339535
OpenAlexW2018852041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.