SynthesisFamilial cancer2015
A risk of digestive tract neoplasms susceptibility in miR-146a and miR-196a2.
Synthesis in Familial cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Association of mir-196a-2 rs11614913 and mir-149 rs2292832 Polymorphisms With Risk of Cancer: An Updated Meta-Analysis.Frontiers in genetics · 2019Pooled it
- Relationship of MicroRNA-146a rs2910164 SNP and tobacco consumption with the susceptibility of digestive system cancer.Discover oncology · 2026Article
- Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis.Biomedicines · 2022Review
- Role of microRNAs in the predisposition to gastrointestinal malignancies.World journal of clinical cases · 2020Review
- MicroRNA Polymorphisms in Cancer: A Literature Analysis.Cancers · 2015Article
- MiR-146a rs2910164 polymorphism is associated with hepatocellular carcinoma: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association studies have identified many genes associated with digestive tract neoplasms. However, the published findings have been conflicting. The aim of our study was to evaluate the involvement of two polymorphisms (miR-146a rs2910164, miR-196a2 rs11614913) in digestive tract neoplasms risk and explore how miR-146a and miR-196a2 influence this risk. Systemic research of the PubMed, EBSCO, CBM and VIP databases was performed. The software STATA 12.0 was used to calculate odd ratios and 95% confidence intervals. There were 14 studies (6,053 cases and 6,527 controls) available for rs2910164 and 15 studies (5,648 cases and 6,607 controls) involved in rs11614913. Rs2910164G>C was statistically significantly associated with digestive tract neoplasms (OR 1.134, 95% CI 1.076-1.194, P < 0.001). In the subgroup analysis by ethnicity, significant association was observed in Asian individuals (OR 1.145, 95% CI 1.084-1.209, P < 0.001). We found a correlation between rs11614913 and only colorectal cancer (OR 1.325, 95% CI 1.102-1.594, P = 0.003). This study suggested that digestive tract neoplasms might associate with miR-146a variants, but not miR-196a2 variants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.