Evidence map›Paper›PMID 25555266›Full record

ArticleAtherosclerosis2015

Subclinical atherosclerosis and increased risk of hearing impairment.

Mary E Fischer, Carla R Schubert, David M Nondahl, Dayna S Dalton, Guan-Hua Huang, Brendan J Keating, Barbara E K Klein, Ronald Klein, Ted S Tweed, Karen J Cruickshanks

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Type 2 Diabetes Mellitus and Hearing Loss: A Prisma Systematic Review and Meta-Analysis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Pooled it
  2. The value of inflammatory biomarkers in the occurrence and prognosis of sudden sensorineural hearing loss: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Audiological Profile in Patients of Chronic Stable Angina with Hearing Loss.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The Value of Plasma Atherogenic Index in Prognosis of Sudden Hearing Loss.The journal of international advanced otology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Allostatic load and risk of hearing impairment.Brain, behavior, & immunity - health · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Mary E FischerDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, 610 Walnut Street, Madison, WI, 53726, USA. Electronic address: fischer@episense.wisc.edu.
Carla R SchubertDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, 610 Walnut Street, Madison, WI, 53726, USA. Electronic address: schubert@episense.wisc.edu.
David M NondahlDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, 610 Walnut Street, Madison, WI, 53726, USA. Electronic address: nondahl@episense.wisc.edu.
Dayna S DaltonDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, 610 Walnut Street, Madison, WI, 53726, USA. Electronic address: dalton@episense.wisc.edu.
Guan-Hua HuangInstitute of Statistics, National Chiao Tung University, 1001 Ta Hsueh Road, Hsinchu, 300, Taiwan. Electronic address: ghuang@stat.nctu.edu.tw.
Brendan J KeatingPerelman School of Medicine, University of Pennsylvania, 1016 Abramson Building, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA. Electronic address: bkeating@mail.med.upenn.edu.
Barbara E K KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, 610 Walnut Street, Madison, WI, 53726, USA. Electronic address: kleinb@epi.ophth.wisc.edu.
Ronald KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, 610 Walnut Street, Madison, WI, 53726, USA. Electronic address: kleinr@epi.ophth.wisc.edu.
Ted S TweedDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, 610 Walnut Street, Madison, WI, 53726, USA. Electronic address: Tedt@tds.net.
Karen J CruickshanksDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, 610 Walnut Street, Madison, WI, 53726, USA; Department of Population Health Sciences, University of Wisconsin, 610 Walnut Street, Madison, WI, 53726, USA. Electronic address: cruickshanks@episense.wisc.edu.
National Yang Ming Chiao Tung University · TWUniversity of Pennsylvania · USUniversity of Wisconsin–Madison · US

Funding

FAMILIAL AND BIRTH COHORT EFFECTS ON THE AGING SENSESR01AG021917 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CRUICKSHANKS, KAREN J · 2004 to 2018
$25.2M
NIA NIH HHS R01 AG021917NIA NIH HHS R01AG021917
6 · The paper itself

Abstract

objectiveThe study's purpose was to test if subclinical atherosclerosis was associated with the risk of developing HI in a large cohort of middle-aged participants.

methodsStudy subjects were members of the Beaver Dam Offspring Study (BOSS), a longitudinal study of adult children of participants in the population-based Epidemiology of Hearing Loss Study (1993-present). BOSS examinations took place in 2005-2008 (baseline) and 2010-2013 (5-year follow-up). The 5-year incidence of hearing impairment was defined as a pure-tone average (PTA) of thresholds at 0.5, 1, 2 and 4 kHz > 25 dB Hearing Level (dB HL) in either ear at follow-up among participants at risk (baseline PTA in both ears < = 25 dB HL; n = 2436, mean age = 47.7 years). Atherosclerosis was measured as the mean carotid intima-media thickness and the presence of carotid artery plaque.

resultsAmong the 1984 participants at-risk with a follow-up audiometric examination, the 5-year incidence of hearing impairment was 8.3% (95% Confidence Interval (C.I.) 7.1, 9.5). With multivariable adjustment, carotid intima-media thickness was positively associated with hearing impairment incidence (Relative Risk (RR) = 1.14 per 0.1 mm, 95% C.I. 1.04, 1.24). The number of sites (0-6) with plaque was also positively associated with the incidence of impairment (RR = 1.16 per site, 95% C.I. 1.01, 1.32).

conclusionAtherosclerosis was associated with the 5-year incidence of hearing impairment in this predominantly middle-aged cohort. Interventions targeting atherosclerosis prevention may help to prevent or delay the onset of hearing impairment.

Indexed as

AdultAgedAsymptomatic DiseasesAudiometry, Pure-ToneAuditory ThresholdCarotid ArteriesCarotid Artery DiseasesCarotid Intima-Media ThicknessFemaleHearing DisordersHumansIncidenceLeast-Squares AnalysisLongitudinal StudiesMaleMiddle AgedCarotid artery plaqueCarotid intima-media thicknessHearing impairmentLongitudinal cohortSubclinical atherosclerosis

Identifiers

PMID25555266
PMCPMC4298463
OpenAlexW1966996973

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.