Evidence map›Paper›PMID 25555132›Full record

ArticleBrain and language2015

Broca's area - thalamic connectivity.

Anastasia A Bohsali, William Triplett, Atchar Sudhyadhom, Joseph M Gullett, Keith McGregor, David B FitzGerald, Thomas Mareci, Keith White, Bruce Crosson

Abstract read
In one paragraph

Article in Brain and language, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Medial Pulvinar Nucleus as a Causal Hub for Heteromodal Naming.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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  8. Article
  9. Syntactic Errors in Older Adults with Depression.Medicina (Kaunas, Lithuania) · 2023
    Article
  10. High-Resolution Tractography Protocol to Investigate the Pathways between Human Mediodorsal Thalamic Nucleus and Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  11. Article
  12. Article
  13. Thalamic Aphasia: a Review.Current neurology and neuroscience reports · 2022
    Review
  14. Article
  15. Article
  16. Subcortical Aphasia.Current neurology and neuroscience reports · 2021
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anastasia A BohsaliDepartment of Veterans Affairs, Rehabilitation Research and Development Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, FL 32608, USA. Electronic address: sokolova@ufl.edu.
William TriplettUniversity of Florida, Department of Biochemistry and Molecular Biology, Gainesville, FL 32610, USA; McKnight Brain Institute, Gainesville, FL 32611, USA.
Atchar SudhyadhomDepartment of Radiology, University of California, San Francisco, CA 90095, USA.
Joseph M GullettDepartment of Veterans Affairs, Rehabilitation Research and Development Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, FL 32608, USA; University of Florida, Department of Clinical and Health Psychology, Gainesville, FL 32610, USA.
Keith McGregorDepartment of Veterans Affairs, Rehabilitation Research and Development Center of Excellence at the Atlanta VA Medical Center, Atlanta, GA 30033, USA; Department of Neurology, Emory University, Atlanta, GA 30322, USA.
David B FitzGeraldDepartment of Veterans Affairs, Rehabilitation Research and Development Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, FL 32608, USA; Neurology Service/127, North Florida/South Georgia Veterans Health System and Department of Neurology, University of Florida, Gainesville, FL 32608, USA.
Thomas MareciUniversity of Florida, Department of Biochemistry and Molecular Biology, Gainesville, FL 32610, USA; McKnight Brain Institute, Gainesville, FL 32611, USA.
Keith WhiteDepartment of Veterans Affairs, Rehabilitation Research and Development Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, FL 32608, USA; University of Florida, Department Psychology, Gainesville, FL 32611, USA.
Bruce CrossonDepartment of Veterans Affairs, Rehabilitation Research and Development Center of Excellence at the Atlanta VA Medical Center, Atlanta, GA 30033, USA; Department of Neurology, Emory University, Atlanta, GA 30322, USA; Department of Psychology, Georgia State University, Atlanta, GA 30303, USA.

Funding

Treating Intention in Aphasia: Neuroplastic SubstratesR01DC007387 · NIDCD · UNIVERSITY OF FLORIDA · PI CROSSON, BRUCE A. · 2006 to 2008
$896k
Effects of exercise intervention on aging-related motor declineIK2RX000956 · VA · VETERANS HEALTH ADMINISTRATION · PI MCGREGOR, KEITH MATTHEW · 2015 to 2017
–
NIDCD NIH HHS R01 DC007387RRD VA IK2 RX000956
6 · The paper itself

Abstract

Broca's area is crucially involved in language processing. The sub-regions of Broca's area (pars triangularis, pars opercularis) presumably are connected via corticocortical pathways. However, growing evidence suggests that the thalamus may also be involved in language and share some of the linguistic functions supported by Broca's area. Functional connectivity is thought to be achieved via corticothalamic/thalamocortical white matter pathways. Our study investigates structural connectivity between Broca's area and the thalamus, specifically ventral anterior nucleus and pulvinar. We demonstrate that Broca's area shares direct connections with these thalamic nuclei and suggest a local Broca's area-thalamus network potentially involved in linguistic processing. Thalamic connectivity with Broca's area may serve to selectively recruit cortical regions storing multimodal features of lexical items and to bind them together during lexical-semantic processing. In addition, Broca's area-thalamic circuitry may enable cortico-thalamo-cortical information transfer and modulation between BA 44 and 45 during language comprehension and production.

Indexed as

ConnectomeAdultBroca AreaHumansMagnetic Resonance ImagingSemanticsThalamusBroca’s areaLanguagePulvinarThalamusTractographyVentral anterior nucleusWhite matter

Identifiers

PMID25555132
PMCPMC10839943

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.