Evidence map›Paper›PMID 25554924›Full record

ReviewCurrent opinion in virology2015

New insights into innate immune restriction of West Nile virus infection.

Helen M Lazear, Michael S Diamond

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Comparative analysis of duck Tembusu virus Cluster 1 and Cluster 2.1 inCurrent research in parasitology & vector-borne diseases · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The role of microglia in viral encephalitis: a review.Journal of neuroinflammation · 2019
    Review
  14. The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions.International journal of molecular sciences · 2018
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Intracellular Antiviral Immunity.Advances in virus research · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Helen M LazearDepartment of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
Michael S DiamondDepartment of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA; Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: diamond@borcim.wustl.edu.

Funding

Systems Biology Identifies Restriction Factors for West Nile VirusU19AI106772 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI LIVNY, MIRON · 2013 to 2017
$26.1M
West Nile Virus and host control of innate defensesU19AI083019 · NIAID · UNIVERSITY OF WASHINGTON · PI GALE, MICHAEL · 2009 to 2018
$22.5M
Innate Immune Control of West Nile VirusR01AI104002 · NIAID · UNIVERSITY OF WASHINGTON · PI DIAMOND, MICHAEL S, GALE, MICHAEL · 2013 to 2017
$3.7M
ISG CONTROL OF FLAVIVIRUS INFECTIONR01AI104972 · NIAID · WASHINGTON UNIVERSITY · PI CHANDA, SUMIT K, DIAMOND, MICHAEL S · 2013 to 2017
$3.0M
NIAID NIH HHS R01 AI104002NIAID NIH HHS R01 AI104972NIAID NIH HHS U19 AI083019NIAID NIH HHS U19 AI106772
6 · The paper itself

Abstract

West Nile virus (WNV) is an encephalitic flavivirus that has provided a valuable experimental system for studying viral pathogenesis and immunity. Although in vitro approaches and mouse models of infection have identified pattern recognition receptor and interferon pathways that control WNV infection, our appreciation of specific antiviral effectors has been more limited. In this review, we highlight recent advances in our understanding of the host factors that restrict WNV infection in mammals and insects, especially those resulting from large-scale screening approaches.

Indexed as

Host-Pathogen InteractionsVirus ReplicationAnimalsDisease Models, AnimalInsectaMammalsModels, BiologicalWest Nile virus

Identifiers

PMID25554924
PMCPMC4456296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.