Trial reportPediatrics2015
Neuroimaging and neurodevelopmental outcome in extremely preterm infants.
Trial report in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
141 citing papers in PubMed, 5 syntheses or guidelines pooled it, 254 citations in OpenAlex.
- Advancements in broadband near-infrared spectroscopy instrumentation for the assessment ofJournal of biomedical optics · 2025Pooled it
- Machine learning techniques for predicting neurodevelopmental impairments in premature infants: a systematic review.Frontiers in artificial intelligence · 2025Pooled it
- Thresholds for surfactant use in preterm neonates: a network meta-analysis.Archives of disease in childhood. Fetal and neonatal edition · 2023Pooled it
- Pooled it
- Advanced neuroimaging and its role in predicting neurodevelopmental outcomes in very preterm infants.Seminars in perinatology · 2016Pooled it
- Association between Term Equivalent Brain Magnetic Resonance Imaging and 2-Year Outcomes in Extremely Preterm Infants: A Report from the Preterm Erythropoietin Neuroprotection Trial Cohort.The Journal of pediatrics · 2021Trial
- Intracranial Hemorrhage and 2-Year Neurodevelopmental Outcomes in Infants Born Extremely Preterm.The Journal of pediatrics · 2021Trial
- Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm.The Journal of pediatrics · 2019Trial
- Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort.The Journal of pediatrics · 2018Trial
- Brain injury in the international multicenter randomized SafeBoosC phase II feasibility trial: cranial ultrasound and magnetic resonance imaging assessments.Pediatric research · 2016Trial
- Explanations and information-giving: clinician strategies used in talking to parents of preterm infants.BMC pediatrics · 2016Trial
- Parent-reported quality of life at school age among children born extremely preterm is associated with non-medical determinants of health and developmental outcomes.Early human development · 2026Article
- Tackling Acquisition of Language in Kids born Preterm (TALK-Preterm): protocol of a prospective cohort study.Research square · 2026Article
- Morphometric alterations of the gray matter of the frontal lobe during childhood in healthy children born prematurely. Repercussions of foetal and postnatal growth restriction.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Factors associated with abnormal screening for autism spectrum disorder among Extremely Preterm Children.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Three-Domain Serial Cranial Ultrasound Phenotypes and Outcomes in Very Preterm Infants with Severe Brain Injury: A Single-Center Cohort Study.Children (Basel, Switzerland) · 2026Article
- Bridging the gap: Translating fetal, infant, and toddler neuroimaging insights into clinical practice.Developmental cognitive neuroscience · 2026Review
- Early ultrasound-based assessment of preterm white matter injury: association with MRI and neurological outcomes.Pediatric radiology · 2026Article
- Neurodevelopmental Trajectories in Preterm Neonates: Integrating Neuroimaging Modalities with Clinical Neurological Outcomes.Diagnostics (Basel, Switzerland) · 2026Review
- Impact of fetal inflammatory response on brain MRI abnormalities in extremely preterm infants.Pediatric research · 2025Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
34 authors at 20 institutions in 1 country.
Funding
Abstract
backgroundExtremely preterm infants are at risk for neurodevelopmental impairment (NDI). Early cranial ultrasound (CUS) is usual practice, but near-term brain MRI has been reported to better predict outcomes. We prospectively evaluated MRI white matter abnormality (WMA) and cerebellar lesions, and serial CUS adverse findings as predictors of outcomes at 18 to 22 months' corrected age.
methodsEarly and late CUS, and brain MRI were read by masked central readers, in a large cohort (n = 480) of infants <28 weeks' gestation surviving to near term in the Neonatal Research Network. Outcomes included NDI or death after neuroimaging, and significant gross motor impairment or death, with NDI defined as cognitive composite score <70, significant gross motor impairment, and severe hearing or visual impairment. Multivariable models evaluated the relative predictive value of neuroimaging while controlling for other factors.
resultsOf 480 infants, 15 died and 20 were lost. Increasing severity of WMA and significant cerebellar lesions on MRI were associated with adverse outcomes. Cerebellar lesions were rarely identified by CUS. In full multivariable models, both late CUS and MRI, but not early CUS, remained independently associated with NDI or death (MRI cerebellar lesions: odds ratio, 3.0 [95% confidence interval: 1.3-6.8]; late CUS: odds ratio, 9.8 [95% confidence interval: 2.8-35]), and significant gross motor impairment or death. In models that did not include late CUS, MRI moderate-severe WMA was independently associated with adverse outcomes.
conclusionsBoth late CUS and near-term MRI abnormalities were associated with outcomes, independent of early CUS and other factors, underscoring the relative prognostic value of near-term neuroimaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.