ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Identification of a conserved set of upregulated genes in mouse skeletal muscle hypertrophy and regrowth.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Assessing the therapeutic potential of PDE-5 inhibitors in adults: Insights from a multi-omics study.Physiological reports · 2026Article
- Skeletal muscle memory: implications for sports, aging and nutrition.Frontiers in nutrition · 2025Review
- Combining Gene Mutation with Expression of Candidate Genes to Improve Diagnosis of Escobar Syndrome.Genes · 2022Article
- Ranolazine Counteracts Strength Impairment and Oxidative Stress in Aged Sarcopenic Mice.Metabolites · 2022Article
- Increased muscle fiber size and pathology with botulinum toxin treatment of upper extremity muscles in cerebral palsy.Current topics in toxicology · 2022Article
- Response of Resistance Exercise-Induced Muscle Protein Synthesis and Skeletal Muscle Hypertrophy Are Not Enhanced After Disuse Muscle Atrophy in Rat.Frontiers in physiology · 2020Article
- Dysregulation of lipid metabolism and appearance of slow myofiber-specific isoforms accompany the development of Wooden Breast myopathy in modern broiler chickens.Scientific reports · 2019Article
- The impact of skeletal muscle contraction on CD146American journal of physiology. Cell physiology · 2019Article
- Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle.eLife · 2019Article
- Article
- Molecular Regulation of Exercise-Induced Muscle Fiber Hypertrophy.Cold Spring Harbor perspectives in medicine · 2018Review
- Postnatal tendon growth and remodeling require platelet-derived growth factor receptor signaling.American journal of physiology. Cell physiology · 2018Article
- Sex differences in tendon structure and function.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Inhibition of platelet-derived growth factor signaling prevents muscle fiber growth during skeletal muscle hypertrophy.FEBS letters · 2017Article
- Changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Comparative Analysis of Muscle Hypertrophy Models Reveals Divergent Gene Transcription Profiles and Points to Translational Regulation of Muscle Growth through Increased mTOR Signaling.Frontiers in physiology · 2017Article
- Hippo Pathway and Skeletal Muscle Mass Regulation in Mammals: A Controversial Relationship.Frontiers in physiology · 2017Review
- Platelet-Rich Plasma Activates Proinflammatory Signaling Pathways and Induces Oxidative Stress in Tendon Fibroblasts.The American journal of sports medicine · 2016Article
- Ribosome Biogenesis is Necessary for Skeletal Muscle Hypertrophy.Exercise and sport sciences reviews · 2016Review
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The purpose of this study was to compare the gene expression profile of mouse skeletal muscle undergoing two forms of growth (hypertrophy and regrowth) with the goal of identifying a conserved set of differentially expressed genes. Expression profiling by microarray was performed on the plantaris muscle subjected to 1, 3, 5, 7, 10, and 14 days of hypertrophy or regrowth following 2 wk of hind-limb suspension. We identified 97 differentially expressed genes (≥2-fold increase or ≥50% decrease compared with control muscle) that were conserved during the two forms of muscle growth. The vast majority (∼90%) of the differentially expressed genes was upregulated and occurred at a single time point (64 out of 86 genes), which most often was on the first day of the time course. Microarray analysis from the conserved upregulated genes showed a set of genes related to contractile apparatus and stress response at day 1, including three genes involved in mechanotransduction and four genes encoding heat shock proteins. Our analysis further identified three cell cycle-related genes at day and several genes associated with extracellular matrix (ECM) at both days 3 and 10. In conclusion, we have identified a core set of genes commonly upregulated in two forms of muscle growth that could play a role in the maintenance of sarcomere stability, ECM remodeling, cell proliferation, fast-to-slow fiber type transition, and the regulation of skeletal muscle growth. These findings suggest conserved regulatory mechanisms involved in the adaptation of skeletal muscle to increased mechanical loading.
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