Evidence map›Paper›PMID 25554792›Full record

ArticleScience (New York, N.Y.)2015

Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.

Daniel E Neafsey, Robert M Waterhouse, Mohammad R Abai, Sergey S Aganezov, Max A Alekseyev, James E Allen, James Amon, Bruno Arcà, Peter Arensburger, Gleb Artemov and 110 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 340 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
340citing papers in PubMed, 1 pooled it
25.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

340 citing papers in PubMed, 1 synthesis or guideline pooled it, 609 citations in OpenAlex.

  1. Pooled it
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  16. Susceptibility ofCurrent research in parasitology & vector-borne diseases · 2026
    Article
  17. Article
  18. Spatial Distribution and Biodiversity ofTropical medicine and infectious disease · 2025
    Article
  19. Article
  20. Article

280 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

120 authors at 20 institutions in 21 countries.

Daniel E NeafseyGenome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. neafsey@broadinstitute.org nbesansk@nd.edu.
Robert M WaterhouseComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Department of Genetic Medicine and Development, University of Geneva Medical School, Rue Michel-Servet 1, 1211 Geneva, Switzerland. Swiss Institute of Bioinformatics, Rue Michel-Servet 1, 1211 Geneva, Switzerland.
Mohammad R AbaiDepartment of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran.
Sergey S AganezovGeorge Washington University, Department of Mathematics and Computational Biology Institute, 45085 University Drive, Ashburn, VA 20147, USA.
Max A AlekseyevGeorge Washington University, Department of Mathematics and Computational Biology Institute, 45085 University Drive, Ashburn, VA 20147, USA.
James E AllenEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
James AmonNational Vector Borne Disease Control Programme, Ministry of Health, Tafea Province, Vanuatu.
Bruno ArcàDepartment of Public Health and Infectious Diseases, Division of Parasitology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Peter ArensburgerDepartment of Biological Sciences, California State Polytechnic-Pomona, 3801 West Temple Avenue, Pomona, CA 91768, USA.
Gleb ArtemovTomsk State University, 36 Lenina Avenue, Tomsk, Russia.
Lauren A AssourDepartment of Computer Science and Engineering, Eck Institute for Global Health, 211B Cushing Hall, University of Notre Dame, Notre Dame, IN 46556, USA.
Hamidreza BasseriDepartment of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran.
Aaron BerlinGenome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
Bruce W BirrenGenome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
Stephanie A BlandinInserm, U963, F-67084 Strasbourg, France. CNRS, UPR9022, IBMC, F-67084 Strasbourg, France.
Andrew I BrockmanDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Thomas R BurkotFaculty of Medicine, Health and Molecular Science, Australian Institute of Tropical Health Medicine, James Cook University, Cairns 4870, Australia.
Austin BurtDepartment of Life Sciences, Imperial College London, Silwood Park Campus, Ascot SL5 7PY, UK.
Clara S ChanComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
Cedric ChauveDepartment of Mathematics, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
Joanna C ChiuDepartment of Entomology and Nematology, One Shields Avenue, University of California-Davis, Davis, CA 95616, USA.
Mikkel ChristensenEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Carlo CostantiniInstitut de Recherche pour le Développement, Unités Mixtes de Recherche Maladies Infectieuses et Vecteurs Écologie, Génétique, Évolution et Contrôle, 911, Avenue Agropolis, BP 64501 Montpellier, France.
Victoria L M DavidsonDivision of Biology, Kansas State University, 271 Chalmers Hall, Manhattan, KS 66506, USA.
Elena DeligianniInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece.
Tania DottoriniDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Vicky DritsouCentre of Functional Genomics, University of Perugia, Perugia, Italy.
Stacey B GabrielGenomics Platform, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
Wamdaogo M GuelbeogoCentre National de Recherche et de Formation sur le Paludisme, Ouagadougou 01 BP 2208, Burkina Faso.
Andrew B HallProgram of Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Mira V HanSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.
Thaung HlaingDepartment of Medical Research, No. 5 Ziwaka Road, Dagon Township, Yangon 11191, Myanmar.
Daniel S T HughesEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Adam M JenkinsBoston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA.
Xiaofang JiangDepartment of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Program of Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Irwin JungreisComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
Evdoxia G KakaniHarvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA. Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.
Maryam KamaliDepartment of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Petri KemppainenComputational Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Ryan C KennedyDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.
Ioannis K KirmitzoglouDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. Bioinformatics Research Laboratory, Department of Biological Sciences, New Campus, University of Cyprus, CY 1678 Nicosia, Cyprus.
Lizette L KoekemoerWits Research Institute for Malaria, Faculty of Health Sciences, and Vector Control Reference Unit, National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham 2131, Johannesburg, South Africa.
Njoroge LabanNational Museums of Kenya, P.O. Box 40658-00100, Nairobi, Kenya.
Nicholas LangridgeEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Mara K N LawniczakDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Manolis LirakisDepartment of Biology, University of Crete, 700 13 Heraklion, Greece.
Neil F LoboEck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.
Ernesto LowyEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Robert M MacCallumDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Chunhong MaoVirginia Bioinformatics Institute, 1015 Life Science Circle, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Gareth MaslenEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Charles MbogoKenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, P.O. Box 230-80108, Kilifi, Kenya.
Jenny McCarthyDepartment of Biological Sciences, California State Polytechnic-Pomona, 3801 West Temple Avenue, Pomona, CA 91768, USA.
Kristin MichelDivision of Biology, Kansas State University, 271 Chalmers Hall, Manhattan, KS 66506, USA.
Sara N MitchellHarvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA.
Wendy MooreDepartment of Entomology, 1140 East South Campus Drive, Forbes 410, University of Arizona, Tucson, AZ 85721, USA.
Katherine A MurphyDepartment of Entomology and Nematology, One Shields Avenue, University of California-Davis, Davis, CA 95616, USA.
Anastasia N NaumenkoDepartment of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Tony NolanDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Eva M NovoaComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
Samantha O'LoughlinDepartment of Life Sciences, Imperial College London, Silwood Park Campus, Ascot SL5 7PY, UK.
Chioma OringanjeDepartment of Entomology, 1140 East South Campus Drive, Forbes 410, University of Arizona, Tucson, AZ 85721, USA.
Mohammad A OshaghiDepartment of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran.
Nazzy PakpourDepartment of Medical Microbiology and Immunology, School of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
Philippos A PapathanosDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. Centre of Functional Genomics, University of Perugia, Perugia, Italy.
Ashley N PeeryDepartment of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Michael PovelonesDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA.
Anil PrakashRegional Medical Research Centre NE, Indian Council of Medical Research, P.O. Box 105, Dibrugarh-786 001, Assam, India.
David P PriceDepartment of Biology, New Mexico State University, Las Cruces, NM 88003, USA. Molecular Biology Program, New Mexico State University, Las Cruces, NM 88003, USA.
Ashok RajaramanDepartment of Mathematics, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
Lisa J ReimerDepartment of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
David C RinkerCenter for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37235, USA.
Antonis RokasCenter for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37235, USA. Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
Tanya L RussellFaculty of Medicine, Health and Molecular Science, Australian Institute of Tropical Health Medicine, James Cook University, Cairns 4870, Australia.
N'Fale SagnonCentre National de Recherche et de Formation sur le Paludisme, Ouagadougou 01 BP 2208, Burkina Faso.
Maria V SharakhovaDepartment of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Terrance SheaGenome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
Felipe A SimãoDepartment of Genetic Medicine and Development, University of Geneva Medical School, Rue Michel-Servet 1, 1211 Geneva, Switzerland. Swiss Institute of Bioinformatics, Rue Michel-Servet 1, 1211 Geneva, Switzerland.
Frederic SimardInstitut de Recherche pour le Développement, Unités Mixtes de Recherche Maladies Infectieuses et Vecteurs Écologie, Génétique, Évolution et Contrôle, 911, Avenue Agropolis, BP 64501 Montpellier, France.
Michel A SlotmanDepartment of Entomology, Texas A&M University, College Station, TX 77807, USA.
Pradya SomboonDepartment of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Vladimir StegniyTomsk State University, 36 Lenina Avenue, Tomsk, Russia.
Claudio J StruchinerFundação Oswaldo Cruz, Avenida Brasil 4365, RJ Brazil. Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Gregg W C ThomasSchool of Informatics and Computing, Indiana University, Bloomington, IN 47405, USA.
Marta TojoDepartment of Physiology, School of Medicine, Center for Research in Molecular Medicine and Chronic Diseases, Instituto de Investigaciones Sanitarias, University of Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.
Pantelis TopalisInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece.
José M C TubioWellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK.
Maria F UngerEck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.
John VontasDepartment of Biology, University of Crete, 700 13 Heraklion, Greece.
Catherine WaltonComputational Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Craig S WildingSchool of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool L3 3AF, UK.
Judith H WillisDepartment of Cellular Biology, University of Georgia, Athens, GA 30602, USA.
Yi-Chieh WuComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Department of Computer Science, Harvey Mudd College, Claremont, CA 91711, USA.
Guiyun YanProgram in Public Health, College of Health Sciences, University of California, Irvine, Hewitt Hall, Irvine, CA 92697, USA.
Evgeny M ZdobnovDepartment of Genetic Medicine and Development, University of Geneva Medical School, Rue Michel-Servet 1, 1211 Geneva, Switzerland. Swiss Institute of Bioinformatics, Rue Michel-Servet 1, 1211 Geneva, Switzerland.
Xiaofan ZhouDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
Flaminia CatterucciaHarvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA. Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.
George K ChristophidesDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Frank H CollinsEck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.
Robert S CornmanDepartment of Cellular Biology, University of Georgia, Athens, GA 30602, USA.
Andrea CrisantiDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. Centre of Functional Genomics, University of Perugia, Perugia, Italy.
Martin J DonnellyDepartment of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. Malaria Programme, Wellcome Trust Sanger Institute, Cambridge CB10 1SJ, UK.
Scott J EmrichDepartment of Computer Science and Engineering, Eck Institute for Global Health, 211B Cushing Hall, University of Notre Dame, Notre Dame, IN 46556, USA.
Michael C FontaineEck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA. Centre of Evolutionary and Ecological Studies (Marine Evolution and Conservation group), University of Groningen, Nijenborgh 7, NL-9747 AG Groningen, Netherlands.
William GelbartDepartment of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
Matthew W HahnDepartment of Biology, Indiana University, Bloomington, IN 47405, USA. School of Informatics and Computing, Indiana University, Bloomington, IN 47405, USA.
Immo A HansenDepartment of Biology, New Mexico State University, Las Cruces, NM 88003, USA. Molecular Biology Program, New Mexico State University, Las Cruces, NM 88003, USA.
Paul I HowellCenters for Disease Control and Prevention, 1600 Clifton Road NE MSG49, Atlanta, GA 30329, USA.
Fotis C KafatosDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Manolis KellisComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
Daniel LawsonEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Christos LouisDepartment of Biology, University of Crete, 700 13 Heraklion, Greece. Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece. Centre of Functional Genomics, University of Perugia, Perugia, Italy.
Shirley LuckhartDepartment of Medical Microbiology and Immunology, School of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
Marc A T MuskavitchBoston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA. Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA.
José M RibeiroLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, 12735 Twinbrook Parkway, Rockville, MD 20852, USA.
Michael A RiehleDepartment of Entomology, 1140 East South Campus Drive, Forbes 410, University of Arizona, Tucson, AZ 85721, USA.
Igor V SharakhovDepartment of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Program of Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Zhijian TuProgram of Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Laurence J ZwiebelDepartments of Biological Sciences and Pharmacology, Institutes for Chemical Biology, Genetics and Global Health, Vanderbilt University and Medical Center, Nashville, TN 37235, USA.
Nora J BesanskyEck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA. neafsey@broadinstitute.org nbesansk@nd.edu.
Imperial College London · GBVirginia Tech · USEuropean Bioinformatics Institute · GBUniversity of Notre Dame · USBroad Institute · USVassar College · USUniversity of California, Davis · USMassachusetts Department of Public Health · USTehran University of Medical Sciences · IRUniversity of Arizona · USUniversity of Crete · GRUniversity of Geneva · CHUniversity of Perugia · ITAustralian Institute of Tropical Health and Medicine · AUBoston College · USCalifornia State Polytechnic University · USCentre National de Recherche et de Formation sur le Paludisme · BFGeorge Washington University Virginia Campus · USIndiana University Bloomington · USInstitute of Molecular Biology and Biotechnology · BG

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI CUOMO, CHRISTINA A · 2014 to 2024
$66.5M
Vector-Borne Diseases: Biology Of Vector Host RelationshipZIAAI000810 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI RIBEIRO, JOSE · 2009 to 2025
$20.8M
GENCODE Resource ProjectU41HG007234 · NHGRI · SANGER INSTITUTE · PI FLICEK, PAUL · 2013 to 2020
$20.3M
TransmissionU19AI089686 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI KAZURA, JAMES WALTER · 2010 to 2016
$9.9M
Ecology of African Highland MalariaR01AI050243 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI YAN, GUIYUN · 2001 to 2018
$8.8M
Systems biology approach to MAPK regulation of malaria infection in A. stephensiR01AI080799 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LUCKHART, SHIRLEY, VODOVOTZ, YORAM · 2009 to 2013
$3.4M
Training Program on Genetic Variation and Human PhenotypesT32GM080178 · NIGMS · VANDERBILT UNIVERSITY · PI COX, NANCY J, SAMUELS, DAVID C · 2007 to 2021
$3.1M
Targeting the reproductive interactome of the malaria vector Anopheles gambiaeR01AI104956 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI CATTERUCCIA, FLAMINIA · 2013 to 2017
$3.0M
Ecological Genomics of Anopheles gambiaeR01AI063508 · NIAID · UNIVERSITY OF NOTRE DAME · PI BESANSKY, NORA JESSIE · 2005 to 2009
$2.7M
Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunityR01AI073745 · NIAID · UNIVERSITY OF ARIZONA · PI RIEHLE, MICHAEL ALLEN · 2008 to 2012
$2.5M
Functional Genomics of Inversion 2La in Anopheles gambiaeR01AI076584 · NIAID · UNIVERSITY OF NOTRE DAME · PI BESANSKY, NORA JESSIE · 2009 to 2013
$2.4M
Medical Research Council G1100339NHGRI NIH HHS U41 HG007234NHGRI NIH HHS U54 HG003067NIAID NIH HHS R01 AI050243NIAID NIH HHS R01 AI063508NIAID NIH HHS R01 AI073745NIAID NIH HHS R01 AI076584NIAID NIH HHS R01 AI080799NIAID NIH HHS R01 AI095842NIAID NIH HHS R01 AI104956NIAID NIH HHS R21 AI101459NIAID NIH HHS R56 AI107263NIAID NIH HHS SC1 AI109055NIAID NIH HHS U19 AI089686NIAID NIH HHS U19 AI110818NIGMS NIH HHS T32 GM080178Wellcome Trust 092654
6 · The paper itself

Abstract

Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.

Indexed as

Evolution, MolecularGenome, InsectAnimalsAnophelesBase SequenceChromosomes, InsectDrosophilaHumansInsect VectorsMalariaMolecular Sequence DataPhylogenySequence Alignment

Identifiers

PMID25554792
PMCPMC4380271
OpenAlexW2136104403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.