Evidence map›Paper›PMID 25554736›Full record

ArticleCurrent protocols in mouse biology2014

Systematic evaluation of skin and adnexa in mutant laboratory mice.

Kathleen A Silva, Victoria E Kennedy, John P Sundberg

Abstract read
In one paragraph

Article in Current protocols in mouse biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kathleen A SilvaThe Jackson Laboratory, Bar Harbor, Maine.
Victoria E Kennedy
John P Sundberg

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
Cpdm: Cloning a Gene That Regulates Eosinophil FunctionR01AR049288 · NIAMS · JACKSON LABORATORY · PI BOWCOCK, ANNE MARY, HOGENESCH, HARM · 2004 to 2016
$5.9M
Model Systems for PXER01AR055225 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI UITTO, JOUNI · 2008 to 2017
$3.2M
Genetics of Alopecia Areata in the C3H/HeJ MouseR01AR056635 · NIAMS · JACKSON LABORATORY · PI SUNDBERG, JOHN PAUL · 2010 to 2014
$1.9M
Discovering Novel Gene Networks for Skin DiseasesR21AR063781 · NIAMS · JACKSON LABORATORY · PI SUNDBERG, JOHN PAUL · 2013 to 2014
$422k
Pathology of Mouse Models of Human DiseaseR13OD010920 · OD · JACKSON LABORATORY · PI SUNDBERG, JOHN PAUL · 2012 to 2021
$200k
NCI NIH HHS P30 CA034196NIAMS NIH HHS R01 AR049288NIAMS NIH HHS R01 AR055225NIAMS NIH HHS R01 AR056635NIAMS NIH HHS R21 AR063781NIH HHS R13 OD010920
6 · The paper itself

Abstract

The skin and its adnexa (hair and nails) comprise one of the easiest organ systems to evaluate, as they are the most accessible. However, mice are small and have lots of very fine hairs of multiple types. Thus, while major abnormalities are obvious, subtle abnormalities or the basis for these defects can be difficult to define. To assist in outlining basic approaches to evaluating mice clinically as well as microscopically with the help of a pathologist, methods are provided here that are used routinely in many laboratories. The mouse is a very useful mammalian model system for studying normal and abnormal (disease) development, and there is a high degree of correlation not only with human biology and medicine but with that of most other mammalian species. Utilizing basic approaches standardizes analysis and provides quality samples for analysis.

Indexed as

Disease Models, AnimalAnimalsFemaleHairHoof and ClawHumansMaleMiceMice, Mutant StrainsPhysical ExaminationSkinSpecimen Handlinghairnailsskintissue collection

Identifiers

PMID25554736
PMCPMC4278579

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.