ArticleHormones and behavior2015
Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female rats.
Article in Hormones and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Importance of apparatus scaling in novel object recognition for juvenile and adult rats.Physiology & behavior · 2026Article
- Role ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Sex-specific effects of prenatal bisphenol A exposure on transcriptome-interactome profiles of autism candidate genes in neural stem cells from offspring hippocampus.Scientific reports · 2025Article
- Sex differences in anxiety and depression: insights from adult rodent models of chronic stress and neural plasticity.Frontiers in behavioral neuroscience · 2025Review
- Phenols and GABAFrontiers in pharmacology · 2024Review
- Prenatal low-dose Bisphenol A exposure impacts cortical development via cAMP-PKA-CREB pathway in offspring.Frontiers in integrative neuroscience · 2024Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Steroid hormones: risk and resilience in women's Alzheimer disease.Frontiers in aging neuroscience · 2023Review
- Steroid Hormone Interaction with Dendritic Spines: Implications for Neuropsychiatric Disease.Advances in neurobiology · 2023Review
- Sex differences in cognition following variations in endocrine status.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Review
- Article
- Housing Environment Affects Pubertal Onset, Anxiety-like Behavior, and Object Interaction in Male and Female Long Evans Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Object recognition tasks in rats: Does sex matter?Frontiers in behavioral neuroscience · 2022Review
- Role of age and neuroinflammation in the mechanism of cognitive deficits in sickle cell disease.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?Frontiers in cellular neuroscience · 2021Review
- Sex differences in dendritic spine density and morphology in auditory and visual cortices in adolescence and adulthood.Scientific reports · 2020Article
- Estrogenic regulation of memory: The first 50 years.Hormones and behavior · 2020Review
- Developmental polychlorinated biphenyl exposure influences adult zebra finch reproductive behaviour.PloS one · 2020Article
- Transgenerational Bisphenol A Causes Deficits in Social Recognition and Alters Postsynaptic Density Genes in Mice.Endocrinology · 2019Article
- Endocrine disrupting chemical exposure and maladaptive behavior during adolescence.Environmental research · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
We have previously demonstrated that adolescent exposure of rats to bisphenol-A (BPA), an environmental endocrine disrupter, increases anxiety, impairs spatial memory, and decreases dendritic spine density in the CA1 region of the hippocampus (CA1) and medial prefrontal cortex (mPFC) when measured in adolescents in both sexes. The present study examined whether the behavioral and morphological alterations following BPA exposure during adolescent development are maintained into adulthood. Male and female, adolescent rats received BPA, 40μg/kg/bodyweight, or control treatments for one week. In adulthood, subjects were tested for anxiety and locomotor activity, spatial memory, non-spatial visual memory, and sucrose preference. Additionally, stress-induced serum corticosterone levels and dendritic spine density in the mPFC and CA1 were measured. BPA-treated males, but not females, had decreased arm visits on the elevated plus maze, but there was no effect on anxiety. Non-spatial memory, object recognition, was also decreased in BPA treated males, but not in females. BPA exposure did not alter spatial memory, object placement, but decreased exploration during the tasks in both sexes. No significant group differences in sucrose preference or serum corticosterone levels in response to a stress challenge were found. However, BPA exposure, regardless of sex, significantly decreased spine density of both apical and basal dendrites on pyramidal cells in CA1 but had no effect in the mPFC. Current data are discussed in relation to BPA dependent changes, which were present during adolescence and did, or did not, endure into adulthood. Overall, adolescent BPA exposure, below the current reference safe daily limit set by the U.S.E.P.A., leads to alterations in some behaviors and neuronal morphology that endure into adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.