ArticleNeurobiology of aging2015
Declines in inflammation predict greater white matter microstructure in older adults.
Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study.Annals of neurology · 2015Trial
- Longitudinal Changes in White Matter Hypointensities in Recurrent Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Association between pulmonary ventilation function and cognitive function among middle-aged and older adults: an observational study from Southwest China.BMC pulmonary medicine · 2024Observational
- Association of critically short telomeres with brain and blood markers of ageing and Alzheimer's disease in older adults.Alzheimer's research & therapy · 2024Article
- Appendicular Lean Mass, Grip Strength, and the Incidence of Dementia Among Older Adults in the Health ABC Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Fractional anisotropy and peripheral cytokine concentrations in outpatients with depressive episode: a diffusion tensor imaging observational study.Scientific reports · 2022Observational
- Inflammatory markers and tract-based structural connectomics in older adults with a preliminary exploration of associations by race.Brain imaging and behavior · 2022Article
- White matter dementia then… and now.Frontiers in neurology · 2022Review
- Cannabis, connectivity, and coming of age: Associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthood.Frontiers in human neuroscience · 2022Article
- Correlation between neutrophil/lymphocyte ratio and cognitive impairment in cerebral small vessel disease patients: A retrospective study.Frontiers in neurology · 2022Article
- Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression.Life (Basel, Switzerland) · 2021Article
- Relationships of inflammation trajectories with white matter volume and integrity in midlife.Brain, behavior, and immunity · 2021Article
- Inflammation, Cognition, and White Matter in Older Adults: An Examination by Race.Frontiers in aging neuroscience · 2020Article
- Lifetime surgical exposure, episodic memory, and forniceal microstructure in older adults.Journal of clinical and experimental neuropsychology · 2019Article
- Emerging Biomarkers in Vascular Cognitive Impairment and Dementia: From Pathophysiological Pathways to Clinical Application.International journal of molecular sciences · 2019Review
- Visceral fat-related systemic inflammation and the adolescent brain: a mediating role of circulating glycerophosphocholines.International journal of obesity (2005) · 2019Article
- Allostatic load and disordered white matter microstructure in overweight adults.Scientific reports · 2018Article
- The association of mid-to late-life systemic inflammation with white matter structure in older adults: The Atherosclerosis Risk in Communities Study.Neurobiology of aging · 2018Article
- Elevated Markers of Inflammation Are Associated With Longitudinal Changes in Brain Function in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Glycerophospholipid Supplementation as a Potential Intervention for Supporting Cerebral Structure in Older Adults.Frontiers in aging neuroscience · 2018Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
Protracted systemic inflammation has been associated with adverse effects on cognition and brain structure and may accelerate neurodegenerative disease processes; however, it is less clear whether changes in inflammation are associated with brain structure. We studied 276 black and white older adults (mean age = 83 years at time of imaging) enrolled in a prospective study of aging. Inflammation (measured with c-reactive protein, CRP) was assessed repeatedly over 6 years (i.e., year 2, 4, 6, and 8). Brain magnetic resonance imaging (MRIs) were obtained at years 10-11 with diffusion tensor imaging; regions of interest included late-myelinating areas vulnerable to aging, including frontal-parietal (superior longitudinal fasciculus [SLF]-dorsal) and temporal (SLF-temporal; uncinate) white matter tracts. Mean CRP values significantly declined (t = -5.54, p < 0.0001) over 6 years, and subject-specific slopes (best linear unbiased predictors of slopes) all showed a decline (mean = -0.57, standard deviation = 0.53) for our participant sample. More than 50% of study participants were still in the moderate to high cardiovascular risk range based on CRP values at year 8. After controlling for demographics, vascular risk factors and MRI white matter hyperintensities, larger decreases in CRP values over time were significantly associated with higher fractional anisotropy in the SLF-dorsal (beta = -0.0052, standard error [SE] = 0.003; 95% confidence interval [CI] = -0.0103 to -0.0025, p = 0.04), SLF-temporal (beta = -0.0109, SE = 0.004; 95% CI = -0.0189 to -0.0029, p = 0.008), and uncinate (beta = -0.0067, SE = 0.003; 95% CI = -0.0132 to -0.0001, p = 0.05) fasciculi. Results suggest that in a prospective cohort of older individuals, faster declines in inflammation over time are related to indicators of white matter health, even after accounting for vascular risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.