Evidence map›Paper›PMID 25554418›Full record

ArticleFEBS letters2015

Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells.

James A Heward, Benoit T Roux, Mark A Lindsay

Open access · hybridAbstract read
In one paragraph

Article in FEBS letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  7. Global epigenomic analysis of KSHV-infected primary effusion lymphoma identifies functionalProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

James A HewardDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, United Kingdom.
Benoit T RouxDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, United Kingdom.
Mark A LindsayDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, United Kingdom. Electronic address: m.a.lindsay@bath.ac.uk.
University of Bath · GB

Funding

Biotechnology and Biological Sciences Research Council BB/K006223/1
6 · The paper itself

Abstract

Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs (eRNAs) induced in human monocytic THP1 cells following activation of the innate immune response by lipopolysaccharide (LPS). Specifically, we have demonstrated that LPS-induced expression of individual eRNAs is mediated through divergent intracellular signalling pathways that includes NF-κB and the mitogen activated protein kinases, extracellular regulated kinase-1/2 and p38.

Indexed as

Enhancer Elements, GeneticCell LineGene Expression RegulationHumansLipopolysaccharidesMAP Kinase Signaling SystemMonocytesNF-kappa Bp38 Mitogen-Activated Protein KinasesRNA, Long NoncodingSignal TransductionLipopolysaccharidesNF-kappa Bp38 Mitogen-Activated Protein KinasesRNA, Long NoncodingEnhancer RNAERK and p38LipopolysaccharideLong non-coding RNAMonocyteNF-κB

Identifiers

PMID25554418
PMCPMC4306547
OpenAlexW2068707459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.