Evidence map›Paper›PMID 25553957›Full record

ReviewAdvanced drug delivery reviews2015

MiRNA inhibition in tissue engineering and regenerative medicine.

Kelsey R Beavers, Christopher E Nelson, Craig L Duvall

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Generation ofJBMR plus · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Chemical Modifications in Nucleic Acid Therapeutics.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Reciprocal communication between FAPs and muscle cells via distinct extracellular vesicle miRNAs in muscle regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kelsey R BeaversInterdisciplinary Graduate Program in Materials Science, Vanderbilt University, Nashville, TN 37235, USA.
Christopher E NelsonDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Craig L DuvallInterdisciplinary Graduate Program in Materials Science, Vanderbilt University, Nashville, TN 37235, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA. Electronic address: craig.duvall@vanderbilt.edu.

Funding

Substrate Mediated siRNA Delivery from Scaffolds to Promote Wound RepairR01EB019409 · NIBIB · VANDERBILT UNIVERSITY · PI Craig Lewis Duvall · 2014 to 2026
$4.0M
Injectable Scaffold for Efficient, Tunable siRNA Delivery to Skin WoundsR21EB012750 · NIBIB · VANDERBILT UNIVERSITY · PI DUVALL, CRAIG LEWIS · 2011 to 2012
$418k
NIBIB NIH HHS R01 EB019409NIBIB NIH HHS R01EB019409NIBIB NIH HHS R21 EB012750NIBIB NIH HHS R21EB012750
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are noncoding RNAs that provide an endogenous negative feedback mechanism for translation of messenger RNA (mRNA) into protein. Single miRNAs can regulate hundreds of mRNAs, enabling miRNAs to orchestrate robust biological responses by simultaneously impacting multiple gene networks. MiRNAs can act as master regulators of normal and pathological tissue development, homeostasis, and repair, which has motivated expanding efforts toward the development of technologies for therapeutically modulating miRNA activity for regenerative medicine and tissue engineering applications. This review highlights the tools currently available for miRNA inhibition and their recent therapeutic applications for improving tissue repair.

Indexed as

Bone and BonesCicatrixGenetic VectorsHumansInflammationKidneyLiverMicroRNAsMuscle, SkeletalMyocardiumNeovascularization, PathologicRegenerationRegenerative MedicineRNA, MessengerTissue EngineeringTissue ScaffoldsMicroRNAsRNA, MessengerAnti-miRMiRNAMiRNA inhibitionRegenerative medicineTissue engineering

Identifiers

PMID25553957
PMCPMC4485980

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.