ReviewAging2014
Questioning the preclinical paradigm: natural, extreme biology as an alternative discovery platform.
Review in Aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- More than one species of the naked mole-rat, a new biomedical model.Communications biology · 2025Article
- Examining the Effects of Hibernation on Germline Mutation Rates in Grizzly Bears.Genome biology and evolution · 2022Article
- Article
- Devising a new dialogue for nutrition science: how life course perspective, U-shaped thinking, whole organism thinking, and language precision contribute to our understanding of biological heterogeneity and forge a fresh advance toward precision medicine.Journal of animal science · 2020Review
- Modeling human disease in rodents by CRISPR/Cas9 genome editing.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Review
- Solving the Neurogenesis Puzzle: Looking for Pieces Outside the Traditional Box.Frontiers in neuroscience · 2017Article
- Seasonal and post-trauma remodeling in cone-dominant ground squirrel retina.Experimental eye research · 2016Review
- Unraveling the message: insights into comparative genomics of the naked mole-rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Mouse models of human disease: An evolutionary perspective.Evolution, medicine, and public health · 2016Article
- Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates.Archives of biochemistry and biophysics · 2015Review
- Regulation of Nrf2 signaling and longevity in naturally long-lived rodents.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The pace at which science continues to advance is astonishing. From cosmology, microprocessors, structural engineering, and DNA sequencing our lives are continually affected by science-based technology. However, progress in treating human ailments, especially age-related conditions such as cancer and Alzheimer's disease, moves at a relative snail's pace. Given that the amount of investment is not disproportionately low, one has to question why our hopes for the development of efficacious drugs for such grievous illnesses have been frustratingly unrealized. Here we discuss one aspect of drug development--rodent models--and propose an alternative approach to discovery research rooted in evolutionary experimentation. Our goal is to accelerate the conversation around how we can move towards more translative preclinical work.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.