Evidence map›Paper›PMID 25553440›Full record

ReviewFrontiers in bioscience (Landmark edition)2015

The role of microRNAs in skeletal muscle health and disease.

Tyler J Kirby, Thomas Chaillou, John J McCarthy

Registry-linked trialAbstract readReview
In one paragraph

Review in Frontiers in bioscience (Landmark edition), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07415837 (Evaluation of the Role of miR-1 in the Pathogenesis and as a Biomarker in Muscular Dystrophies and Congenital Myopathies), which is not on this map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07415837 narecruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Role of miR-1 in the Pathogenesis and as a Biomarker in Muscular Dystrophies and Congenital Myopathies

TypeinterventionalSponsorUniversity Hospital, Clermont-FerrandRan2026 to 2029Enrolled104ConditionsDuchenne / Becker Muscular Dystrophy, Dystrophia Myotonica 1, Congenital Myopathies, Healthy ParticipantsArmsdosage of blood biomarker miR1
3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Epigenetics of Myotonic Dystrophies: A Minireview.International journal of molecular sciences · 2021
    Review
  11. Mechanisms of exercise as a preventative measure to muscle wasting.American journal of physiology. Cell physiology · 2021
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tyler J KirbyCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA, 2Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.
Thomas ChaillouCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA, 2Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.
John J McCarthyCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA, 2Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.

Funding

The role of satellite cells in adult skeletal muscle growth and maintenanceR01AR060701 · NIAMS · UNIVERSITY OF KENTUCKY · PI MCCARTHY, JOHN JOSEPH, PETERSON, CHARLOTTE A. · 2010 to 2019
$3.3M
BetaCatenin Regulation of Skeletal Muscle HypertrophyR01AR061939 · NIAMS · UNIVERSITY OF KENTUCKY · PI ESSER, KARYN A, MCCARTHY, JOHN JOSEPH · 2012 to 2016
$1.7M
NIAMS NIH HHS AR061939NIAMS NIH HHS R01 AR060701NIAMS NIH HHS R01 AR061939
6 · The paper itself

Abstract

Over the last decade non-coding RNAs have emerged as importance regulators of gene expression. In particular, microRNAs are a class of small RNAs of ∼ 22 nucleotides that repress gene expression through a post-transcriptional mechanism. MicroRNAs have been shown to be involved in a broader range of biological processes, both physiological and pathological, including myogenesis, adaptation to exercise and various myopathies. The purpose of this review is to provide a comprehensive summary of what is currently known about the role of microRNAs in skeletal muscle health and disease.

Indexed as

HumansMicroRNAsMuscle DevelopmentMuscle, SkeletalMuscular AtrophyMuscular DiseasesMicroRNAs

Identifiers

PMID25553440
PMCPMC4853752

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.