ArticleChronic obstructive pulmonary diseases (Miami, Fla.)2014
Repeatability and Sample Size Assessment Associated with Computed Tomography-Based Lung Density Metrics.
Article in Chronic obstructive pulmonary diseases (Miami, Fla.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The Use of Computed Tomography Densitometry for the Assessment of Emphysema in Clinical Trials: A Position Paper from the Fleischner Society.American journal of respiratory and critical care medicine · 2025Pooled it
- Automated CT-based measurements of radial and longitudinal expansion of airways due to breathing-related lung volume change.Medical physics · 2025Article
- Automated CT-based decoupling of the effects of airway narrowing and wall thinning on airway counts in chronic obstructive pulmonary disease.The British journal of radiology · 2025Article
- Repeatability of Pulmonary Quantitative Computed Tomography Measurements in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2023Article
- MULTI-VIEW CNN FOR TOTAL LUNG VOLUME INFERENCE ON CARDIAC COMPUTED TOMOGRAPHY.Proceedings. IEEE International Symposium on Biomedical Imaging · 2023Article
- Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.Annals of the American Thoracic Society · 2023Article
- A CT-Based Automated Algorithm for Airway Segmentation Using Freeze-and-Grow Propagation and Deep Learning.IEEE transactions on medical imaging · 2021Article
- Inter- and intra-software reproducibility of computed tomography lung density measurements.Medical physics · 2020Article
- LOCALLY ADAPTIVE HALF-MAX METHODS FOR AIRWAY LUMEN-AREA AND WALL-THICKNESS AND THEIR REPEAT CT SCAN REPRODUCIBILITY.Proceedings. IEEE International Symposium on Biomedical Imaging · 2020Article
- Effects of acquisition method and reconstruction algorithm for CT number measurement on standard-dose CT and reduced-dose CT: a QIBA phantom study.Japanese journal of radiology · 2019Article
- Impact of advanced detector technology and iterative reconstruction on low-dose quantitative assessment of lung computed tomography density in a biological lung model.Medical physics · 2018Article
- A four-dimensional computed tomography comparison of healthy and asthmatic human lungs.Journal of biomechanics · 2017Article
- Article
- Standardizing CT lung density measure across scanner manufacturers.Medical physics · 2017Article
- LINKING LUNG AIRWAY STRUCTURE TO PULMONARY FUNCTION VIA COMPOSITE BRIDGE REGRESSION.The annals of applied statistics · 2016Article
- SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs.American journal of respiratory and critical care medicine · 2016Article
- Quantitative Dual-Energy Computed Tomography Supports a Vascular Etiology of Smoking-induced Inflammatory Lung Disease.American journal of respiratory and critical care medicine · 2016Article
- Assessment of regional ventilation and deformation using 4D-CT imaging for healthy human lungs during tidal breathing.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Improved CT-based estimate of pulmonary gas trapping accounting for scanner and lung-volume variations in a multicenter asthmatic study.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
RATIONALE AND
objectivesDensity-based metrics assess severity of lung disease but vary with lung inflation and method of scanning. The aim of this study was to evaluate the repeatability of single center, CT-based density metrics of the lung in a normal population and assess study sample sizes needed to detect meaningful changes in lung density metrics when scan parameters and volumes are tightly controlled. MATERIALS AND
methodsThirty-seven subjects (normal smokers and non-smokers) gave consent to have randomly assigned repeated, breath-held scans at either inspiration (90% vital capacity: TLC) or expiration (20% vital capacity: FRC). Repeated scans were analyzed for: mean lung density (MLD), 15
resultsInter-scan difference measurements were small for density metrics (ICC > 0.80) and average ICCs for whole lung alpha
conclusionA meaningful sample size was predicted from this study using volume-controlled normal subjects in a controlled imaging environment. Under proper breath-hold conditions, high repeatability was obtained in cohorts of normal smokers and non-smokers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.