Evidence map›Paper›PMID 25553328›Full record

ArticleCMAJ open2014

Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study.

Ram Venkatesh Anantha, Januvi Jegatheswaran, Daniel Luke Pepe, Fran Priestap, Johan Delport, S M Mansour Haeryfar, John K McCormick, Tina Mele

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CMAJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. A Retrospective Study ofDiagnostics (Basel, Switzerland) · 2023
    Article
  5. [Clinical characteristics and prognosis of Staphylococcus aureus bacteremia].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022
    Article
  6. Article
  7. Epidemiology, antimicrobial resistance and outcomes ofThe Lancet regional health. Western Pacific · 2022
    Article
  8. Investigational agents for the treatment of methicillin-resistantExpert opinion on investigational drugs · 2022
    Article
  9. Antibiotic Stewardship inAntibiotics (Basel, Switzerland) · 2020
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ram Venkatesh AnanthaDivision of General Surgery, Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. ; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ont.
Januvi JegatheswaranSchulich School of Medicine and Dentistry, Western University, London, Ont.
Daniel Luke PepeSchulich School of Medicine and Dentistry, Western University, London, Ont.
Fran PriestapDivision of Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont.
Johan DelportDepartment of Pathology, Schulich School of Medicine and Dentistry, Western University, London, Ont.
S M Mansour HaeryfarDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ont.
John K McCormickDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ont.
Tina MeleDivision of General Surgery, Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. ; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ont. ; Division of Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionStaphylococcus aureus bacteremia is associated with significant morbidity and mortality. Given the paucity of recent Canadian data, we estimated the mortality rate associated with S. aureus bacteremia in a tertiary care hospital and identified risk factors associated with mortality.

methodsWe retrospectively reviewed the records of adults with S. aureus bacteremia admitted to a tertiary care centre in southwestern Ontario between 2008 and 2012. Cox regression analysis was used to evaluate associations between predictor variables and all-cause, in-hospital, and 90-day postdischarge mortality.

resultsOf the 925 patients involved in the study, 196 (21.2%) died in hospital and 62 (6.7%) died within 90 days after discharge. Risk factors associated with in-hospital and all-cause mortality included age, sepsis (adjusted hazard ratio [adjusted HR] 1.49, 95% confidence interval [CI] 1.08-2.06, p = 0.02), admission to the intensive care unit (adjusted HR 3.78, 95% CI 2.85-5.02, p < 0.0001), hepatic failure (adjusted HR 3.36, 95% CI 1.91-5.90, p < 0.0001) and metastatic cancer (adjusted HR 2.58, 95% CI 1.77-3.75, p < 0.0001). Methicillin resistance, hepatic failure, cerebrovascular disease, chronic obstructive pulmonary disease and metastatic cancer were associated with postdischarge mortality.

interpretationThe all-cause mortality rate in our cohort was 27.9%. Identification of predictors of mortality may guide empiric therapy and provide prognostic clarity for patients with S. aureus bacteremia.

Identifiers

PMID25553328
PMCPMC4270209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.