ArticleSports health2015
Current concepts: the role of mesenchymal stem cells in the management of knee osteoarthritis.
Article in Sports health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03580148 (A Randomized Trial of Cortisone Injection Versus Bone Marrow Aspirate Injection Therapy for Glenohumeral Osteoarthritis), which is not on this map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Trial of Cortisone Injection Versus Bone Marrow Aspirate Injection Therapy for Glenohumeral Osteoarthritis
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Efficacy and safety of mesenchymal stem cells in knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.Stem cell research & therapy · 2025Pooled it
- Effectiveness of combined regenerative medicine and exercise therapy for patients with knee osteoarthritis: a scoping review.Frontiers in rehabilitation sciences · 2025Pooled it
- Transplantation of three mesenchymal stem cells for knee osteoarthritis, which cell and type are more beneficial? a systematic review and network meta-analysis.Journal of orthopaedic surgery and research · 2024Pooled it
- Pooled it
- Multi-compositional MRI evaluation of repair cartilage in knee osteoarthritis with treatment of allogeneic human adipose-derived mesenchymal progenitor cells.Stem cell research & therapy · 2019Trial
- Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation.Stem cells translational medicine · 2019Trial
- Intra-articular injections of expanded mesenchymal stem cells with and without addition of platelet-rich plasma are safe and effective for knee osteoarthritis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Trial
- Two years efficacy and safety outcomes of using allogeneic, pooled mesenchymal stromal cells for osteoarthritis of knee in a double-blind randomized placebo-controlled phase 3 study.Osteoarthritis and cartilage open · 2026Article
- Biologic and regenerative strategies for osteoarthritis: advances in MSC, exosome, and PRP based therapies.Frontiers in pharmacology · 2026Review
- GDF11 protects against mitochondrial-dysfunction-dependent NLRP3 inflammasome activation to attenuate osteoarthritis.Journal of advanced research · 2025Article
- The Current State of Osteoarthritis Treatment Options Using Stem Cells for Regenerative Therapy: A Review.International journal of molecular sciences · 2023Review
- Intravenous injection of adipose-derived mesenchymal stromal cells benefits gait and inflammation in a spontaneous osteoarthritis model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Synovium Derived Mesenchymal Stromal Cells (Sy-MSCs): A Promising Therapeutic Paradigm in the Management of Knee Osteoarthritis.Indian journal of orthopaedics · 2022Review
- Enhancement of acellular cartilage matrix scaffold by Wharton's jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration.Bioactive materials · 2021Article
- Intra-articular injection of hUC-MSCs expressing miR-140-5p induces cartilage self-repairing in the rat osteoarthritis.Journal of bone and mineral metabolism · 2020Article
- Comparative Analysis of Adipose-Derived Stromal Cells and Their Secretome for Auricular Cartilage Regeneration.Stem cells international · 2020Article
- Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies.Pain research & management · 2020Review
- Bone Marrow Mesenchymal Stem Cell Therapy and Related Bone Marrow-Derived Orthobiologic Therapeutics.Current reviews in musculoskeletal medicine · 2019Review
- Icariin inhibits chondrocyte apoptosis and angiogenesis by regulating the TDP-43 signaling pathway.Molecular genetics & genomic medicine · 2019Article
- Transplantation of human ESC-derived mesenchymal stem cell spheroids ameliorates spontaneous osteoarthritis in rhesus macaques.Theranostics · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe number of adults with osteoarthritis in the United States is expected to nearly double from 21.4 million in 2005 to 41.1 million by 2030. As a result, medical costs and associated comorbidity will exponentially increase in the coming decades. In the past decade, mesenchymal stem cells (MSCs) have emerged as a novel treatment for degenerative joint disease. EVIDENCE ACQUISITION: PubMed (from 1990 to 2013) was searched to identify relevant studies. Reference lists of included studies were also reviewed. STUDY
designClinical review. LEVEL OF EVIDENCE: Level 3.
resultsWe identified 9 animal and 7 human studies investigating the use of MSCs in the treatment of osteoarthritis, with varying levels of support for this therapy.
conclusionWhile MSCs have shown potential for improving function and decreasing inflammation in animal studies, translation to patients is still in question. There is a great deal of heterogeneity in treatment methods. Standardizing the manufacturing and characterization of MSCs will allow for better comparisons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.