ArticleTheranostics2015
Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery.
Article in Theranostics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
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- The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery.Journal of nanobiotechnology · 2022Review
- Simultaneous multipurpose fluorescence imaging with IRDye® 800BK during laparoscopic surgery.Surgical endoscopy · 2021Article
- Differential Morphological Diagnosis of Various Forms of Congenital Hyperinsulinism in Children.Frontiers in endocrinology · 2021Article
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- Near-Infrared Contrast Agents for Bone-Targeted Imaging.Tissue engineering and regenerative medicine · 2019Review
- Crystallization of high aspect ratio HKUST-1 thin films in nanoconfined channels for selective small molecule uptake.Nanoscale advances · 2019Article
- Introduction of various substitutions to the methine bridge of heptamethine cyanine dyes Via substituted dianil linkers.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2018Article
- TricarbocyanineChemical science · 2018Article
- Multivalent Mannose-Decorated NIR Nanoprobes for Targeting Pan Lymph Nodes.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2018Article
- Structure-Inherent Targeting of Near-Infrared Fluorophores for Image-Guided Surgery.Chonnam medical journal · 2017Review
- Intraoperative Near-Infrared Fluorescence Imaging of Thymus in Preclinical Models.The Annals of thoracic surgery · 2017Article
- Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging.ACS omega · 2017Article
- Fluorescence-Guided Surgery.Frontiers in oncology · 2017Review
- Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy.Theranostics · 2017Article
- Rapid fluorescence imaging of spinal cord following epidural administration of a nerve-highlighting fluorophore.Theranostics · 2017Article
- Targeted multimodal nano-reporters for pre-procedural MRI and intra-operative image-guidance.Biomaterials · 2016Article
- Endocrine-specific NIR fluorophores for adrenal gland targeting.Chemical communications (Cambridge, England) · 2016Article
- Near-Infrared Illumination of Native Tissues for Image-Guided Surgery.Journal of medicinal chemistry · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectivePancreas-related complications are some of the most serious ones in abdominal surgery. The goal of this study was to develop and validate novel near-infrared (NIR) fluorophores that would enable real-time pancreas imaging to avoid the intraoperative pancreatic injury.
designAfter initial screening of a large NIR fluorophore library, the performance of 3 selected pancreas-targeted 700 nm NIR fluorophores, T700-H, T700-F, and MB, were quantified in mice, rats, and pigs. Dose ranging using 25 and 100 nmol, and 2.5 µmol of T700-F, and its imaging kinetics over a 4 h period were tested in each species. Three different 800 nm NIR fluorophores were employed for dual-channel FLARE™ imaging in pigs: 2 μmol of ZW800-1 for vessels and kidney, 1 μmol of ZW800-3C for lymph nodes, and 2 μmol of ESNF31 for adrenal glands.
resultsT700-F demonstrated the highest signal to background ratio (SBR), with peak SBR at 4 h postinjection in mice. In pigs, T700-F produced an SBR≥2 against muscle, spleen, and lymph nodes for up to 8 h after a single intravenous injection. The combination of T700-F with each 800 nm NIR fluorophore provided simultaneous dual-channel intraoperative imaging of pancreas with surrounding organs in real time.
conclusionPancreas-targeted NIR fluorophores combined with the FLARE dual-channel imaging system enable the real-time intraoperative pancreas imaging which helps surgeons perform safer and more curative abdominal surgeries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.