ArticleEvolutionary applications2014
Additive genetic variation for tolerance to estrogen pollution in natural populations of Alpine whitefish (Coregonus sp., Salmonidae).
Article in Evolutionary applications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Advancing the Spatiotemporal Dimension of Wildlife-Pollution Interactions.Environmental science & technology letters · 2025Review
- Steroid hormones in fish, caution for present and future: A review.Toxicology reports · 2024Review
- Testing for population differences in evolutionary responses to pesticide pollution in brown trout (Evolutionary applications · 2021Article
- Health Effects and Life Stage Sensitivities in Zebrafish Exposed to an Estrogenic Wastewater Treatment Works Effluent.Frontiers in endocrinology · 2021Article
- Low adaptive potential for tolerance to ethynylestradiol, but also low toxicity, in a grayling population (Thymallus thymallus).BMC evolutionary biology · 2019Article
- Sperm cryopreservation reduces offspring growth.Proceedings. Biological sciences · 2019Article
- Sex-specific changes in gene expression in response to estrogen pollution around the onset of sex differentiation in grayling (Salmonidae).BMC genomics · 2019Article
- No additive genetic variance for tolerance to ethynylestradiol exposure in natural populations of brown trout (Evolutionary applications · 2019Article
- Consumption of carotenoids not increased by bacterial infection in brown trout embryos (Salmo trutta).PloS one · 2018Article
- Maternal allocation of carotenoids increases tolerance to bacterial infection in brown trout.Oecologia · 2017Article
- Demographic and genetic consequences of disturbed sex determination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Environmental stress linked to consumption of maternally derived carotenoids in brown trout embryos (Ecology and evolution · 2017Article
- Hormonally active phytochemicals and vertebrate evolution.Evolutionary applications · 2017Article
- Veterinary pharmaceuticals in aqueous systems and associated effects: an update.Environmental science and pollution research international · 2017Review
- Genetic correlations and little genetic variance for reaction norms may limit potential for adaptation to pollution by ionic and nanoparticulate silver in a whitefish (Salmonidae).Ecology and evolution · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionary potential of natural populations to adapt to anthropogenic threats critically depends on whether there exists additive genetic variation for tolerance to the threat. A major problem for water-dwelling organisms is chemical pollution, and among the most common pollutants is 17α-ethinylestradiol (EE2), the synthetic estrogen that is used in oral contraceptives and that can affect fish at various developmental stages, including embryogenesis. We tested whether there is variation in the tolerance to EE2 within Alpine whitefish. We sampled spawners from two species of different lakes, bred them in vitro in a full-factorial design each, and studied growth and mortality of embryos. Exposure to EE2 turned out to be toxic in all concentrations we tested (≥1 ng/L). It reduced embryo viability and slowed down embryogenesis. We found significant additive genetic variation in EE2-induced mortality in both species, that is, genotypes differed in their tolerance to estrogen pollution. We also found maternal effects on embryo development to be influenced by EE2, that is, some maternal sib groups were more susceptible to EE2 than others. In conclusion, the toxic effects of EE2 were strong, but both species demonstrated the kind of additive genetic variation that is necessary for an evolutionary response to this type of pollution.
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