ArticleDose-response : a publication of International Hormesis Society2014
From ischemic conditioning to 'hyperconditioning': clinical phenomenon and basic science opportunity.
Article in Dose-response : a publication of International Hormesis Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Limited Clinical Utility of Remote Ischemic Conditioning in Renal Transplantation: A Meta-Analysis of Randomized Controlled Trials.PloS one · 2017Pooled it
- Effects of remote ischemic preconditioning on coronary blood flow and microcirculation.BMC cardiovascular disorders · 2023Trial
- Early Immunological Effects of Ischemia-Reperfusion Injury: No Modulation by Ischemic Preconditioning in a Randomised Crossover Trial in Healthy Humans.International journal of molecular sciences · 2019Trial
- A Double Blind Randomized Clinical Trial of Remote Ischemic Conditioning in Live Donor Renal Transplantation.Medicine · 2015Trial
- Effects of occlusion pressure on hemodynamic responses recorded by near-infrared spectroscopy across two visits.Frontiers in physiology · 2024Article
- Acute effects of one-leg standing on arterial stiffness in older women: Role of the vision condition and standing dose.Frontiers in physiology · 2022Article
- Effects of remote ischemic preconditioning (RIPC) and chronic remote ischemic preconditioning (cRIPC) on levels of plasma cytokines, cell surface characteristics of monocytes and in-vitro angiogenesis: a pilot study.Basic research in cardiology · 2021Article
- Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function.Basic research in cardiology · 2021Review
- Atg5 knockdown induces age-dependent cardiomyopathy which can be rescued by repeated remote ischemic conditioning.Basic research in cardiology · 2021Article
- Perioperative Cardioprotection by Remote Ischemic Conditioning.International journal of molecular sciences · 2019Review
- The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection.Cardiovascular research · 2019Review
- Ischaemic and hypoxic conditioning: potential for protection of vital organs.Experimental physiology · 2019Review
- Circulating mediators of remote ischemic preconditioning: search for the missing link between non-lethal ischemia and cardioprotection.Oncotarget · 2019Review
- Physical Exercise Reduces Cytotoxicity and Up-Regulates Nrf2 and UPR Expression in Circulating Cells of Peripheral Artery Disease Patients: An Hypoxic Adaptation?Journal of atherosclerosis and thrombosis · 2018Article
- Diverse Ischemic Postconditioning Protocols Affect the Infarction Size in Focal Ischemic Stroke.Journal of cerebrovascular and endovascular neurosurgery · 2018Article
- Cardioprotection by remote ischemic conditioning and its signal transduction.Pflugers Archiv : European journal of physiology · 2017Review
- The effect of 1 week of repeated ischaemic leg preconditioning on simulated Keirin cycling performance: a randomised trial.BMJ open sport & exercise medicine · 2017Article
- Remote ischaemic conditioning in the context of type 2 diabetes and neuropathy: the case for repeat application as a novel therapy for lower extremity ulceration.Cardiovascular diabetology · 2016Review
- Ischaemic conditioning: pitfalls on the path to clinical translation.British journal of pharmacology · 2015Review
- Remote ischemic conditioning.Journal of the American College of Cardiology · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Thousands of articles have been published on the topic of ischemic conditioning. Nevertheless, relatively little attention has been given to assessment of conditioning's dose-response characteristics. Specifically, the consequences of multiple conditioning episodes, what we will term "hyperconditioning", have seldom been examined. We propose that hyperconditioning warrants investigation because it; (1) may be of clinical importance, (2) could provide insight into conditioning mechanisms, and (3) might result in development of novel models of human disease. The prevalence of angina pectoris and intermittent claudication is sufficiently high and the potential for daily ischemia-reperfusion episodes sufficiently large that hyperconditioning is a clinically relevant phenomenon. In basic science, attenuation of conditioning-mediated infarct size reduction found in some studies after hyperconditioning offers a possible means to facilitate further discernment of cardioprotective signaling pathways. Moreover, hyperconditioning's impact extends beyond cytoprotection to tissue structural elements. Several studies demonstrate that hyperconditioning produces collagen injury (primarily fiber breakage). Such structural impairment could have adverse clinical consequences; however, in laboratory studies, selective collagen damage could provide the basis for models of cardiac rupture and dilated cardiomyopathy. Accordingly, we propose that hyperconditioning represents the dark, but potentially illuminating, side of ischemic conditioning - a paradigm that merits attention and prospective evaluation.
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